28737-33-9 Usage
Description
3-Bromoindole-2-carboxylic acid is an organic compound characterized by a pinkish-beige crystalline powder form. It is a derivative of indole-2-carboxylic acid with a bromine atom attached at the 3-position, which imparts unique chemical properties to the molecule. 3-BROMOINDOLE-2-CARBOXYLIC ACID has been of interest in the field of medicinal chemistry and has been studied for its potential applications in various areas.
Uses
Used in Pharmaceutical Research:
3-Bromoindole-2-carboxylic acid is used as a research compound for studying the effect of mimetic CDK9 inhibitors on HIV-1-activated transcription. This application is significant in the development of novel therapeutic strategies targeting the regulation of gene expression in HIV-1 infected cells, potentially leading to the discovery of new treatments for HIV/AIDS.
Used in Chemical Synthesis:
As a chemical intermediate, 3-bromoindole-2-carboxylic acid can be used in the synthesis of various pharmaceuticals, agrochemicals, and other organic compounds. Its unique structure and reactivity make it a valuable building block for the creation of new molecules with potential applications in different industries.
Used in Material Science:
3-BROMOINDOLE-2-CARBOXYLIC ACID's properties may also find applications in material science, where it could be used to develop new materials with specific characteristics, such as light absorption, emission, or other optical properties. This could be particularly relevant in the development of advanced materials for electronics, photonics, or other high-tech applications.
Check Digit Verification of cas no
The CAS Registry Mumber 28737-33-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,8,7,3 and 7 respectively; the second part has 2 digits, 3 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 28737-33:
(7*2)+(6*8)+(5*7)+(4*3)+(3*7)+(2*3)+(1*3)=139
139 % 10 = 9
So 28737-33-9 is a valid CAS Registry Number.
InChI:InChI=1/C9H6BrNO2/c10-7-5-3-1-2-4-6(5)11-8(7)9(12)13/h1-4,11H,(H,12,13)/p-1
28737-33-9Relevant articles and documents
Efficient and Practical Oxidative Bromination and Iodination of Arenes and Heteroarenes with DMSO and Hydrogen Halide: A Mild Protocol for Late-Stage Functionalization
Song, Song,Sun, Xiang,Li, Xinwei,Yuan, Yizhi,Jiao, Ning
supporting information, p. 2886 - 2889 (2015/06/30)
An efficient and practical system for inexpensive bromination and iodination of arenes as well as heteroarenes by using readily available dimethyl sulfoxide (DMSO) and HX (X = Br, I) reagents is reported. This mild oxidative system demonstrates a versatile protocol for the synthesis of aryl halides. HX (X = Br, I) are employed as halogenating reagents when combined with DMSO which participates in the present chemistry as a mild and inexpensive oxidant. This oxidative system is amenable to late-stage bromination of natural products. The kilogram-scale experiment (>95% yield) shows great potential for industrial application.
COMPOUNDS
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, (2008/06/13)
This invention relates to novel carboxylic acid indole compounds and compositions for use in the treatment of disease states mediated by the chemokine, Interleukin-8 (IL-8).
