2875-25-4 Usage
Description
(E)-1-(2-hydroxyphenyl)-3-pyridin-3-yl-prop-2-en-1-one, with the molecular formula C15H11NO2, is a chemical compound featuring a pyridine ring and a phenolic group connected to a propenone moiety. (E)-1-(2-hydroxyphenyl)-3-pyridin-3-yl-prop-2-en-1-one is recognized for its diverse biological activities and potential applications in various fields, particularly in organic synthesis and medicinal chemistry.
Uses
Used in Pharmaceutical Industry:
(E)-1-(2-hydroxyphenyl)-3-pyridin-3-yl-prop-2-en-1-one is used as an active pharmaceutical ingredient for its demonstrated antibacterial, antifungal, and anti-inflammatory properties. Its multifaceted pharmacological potential makes it a promising candidate for the development of new drugs to combat various infections and inflammatory conditions.
Used in Cancer Treatment Research:
In the field of oncology, (E)-1-(2-hydroxyphenyl)-3-pyridin-3-yl-prop-2-en-1-one is used as a compound under investigation for its potential role in the treatment of cancer. Its biological activities suggest that it may have therapeutic benefits in targeting cancer cells and modulating the disease's progression.
Used in Alzheimer's Disease Research:
(E)-1-(2-hydroxyphenyl)-3-pyridin-3-yl-prop-2-en-1-one is also used as a compound in the research and development of treatments for Alzheimer's disease. Its diverse pharmacological profile indicates that it may contribute to the discovery of novel therapeutic approaches for this neurodegenerative condition.
Organic Synthesis:
(E)-1-(2-hydroxyphenyl)-3-pyridin-3-yl-prop-2-en-1-one is used as a key intermediate in organic synthesis, particularly for the creation of complex molecular structures with potential applications in various chemical and pharmaceutical processes.
Medicinal Chemistry:
In medicinal chemistry, (E)-1-(2-hydroxyphenyl)-3-pyridin-3-yl-prop-2-en-1-one serves as a valuable compound for further research and development. Its structural features and biological activities make it an attractive starting point for the design and synthesis of new drugs targeting a range of diseases and conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 2875-25-4 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 2,8,7 and 5 respectively; the second part has 2 digits, 2 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 2875-25:
(6*2)+(5*8)+(4*7)+(3*5)+(2*2)+(1*5)=104
104 % 10 = 4
So 2875-25-4 is a valid CAS Registry Number.
InChI:InChI=1/C14H11NO2/c16-13-6-2-1-5-12(13)14(17)8-7-11-4-3-9-15-10-11/h1-10,16H/b8-7+
2875-25-4Relevant articles and documents
Thallium(III) p-tosylate-mediated oxidative [1,2] rearrangement of 2-naphthyl and 2-heteroarylchromanones
Kurapati, Chidvilas,Muthukrishnan, Murugan,Singh, Om V.,Gundla, Rambabu
supporting information, p. 172 - 177 (2021/10/29)
A practical and effective approach towards the synthesis of 3-heteroaryl-4H-chromen-4-ones by the oxidative [1,2] rearrangement of the respective 2-heteroaryl chroman-4-ones using thallium(III) p-tosylate is presented. The oxidative rearrangement of α- an
Ru, Rh and Ir metal complexes of pyridyl chalcone derivatives: Their potent antibacterial activity, comparable cytotoxicity potency and selectivity to cisplatin
Banothu, Venkanna,Dkhar, Lincoln,Kaminsky, Werner,Kollipara, Mohan Rao,Phillips, Roger M.,Pinder, Emma
, (2020/05/29)
Half sandwich ruthenium, rhodium and iridium complexes containing pyridyl chalcone analogues (L1 and L2) are prepared by the reaction of [(arene)M(μ-Cl)Cl]2 (arene = benzene, p-cymene, Cp*) and (M = Ru, Rh/Ir)] with L1 and L2 in 1:2 (M:L) ratio. Eight neutral mononuclear complexes (1–8) were obtained and characterized using FT-IR, 1H NMR, 13C NMR, ESI mass and UV–Vis spectroscopic methods. The molecular structures of complexes 2, 4, 5 and 7 are established by single crystal X-ray diffraction studies. Antibacterial studies were tested against three strains of bacterial microorganisms Staphylococcus aureus (gram +ve), Klebsiella pneumoniae (gram ?ve) and Escherichia coli (gram ?ve). Further the cytotoxicity study of the pyridyl chalcone derivatives and their complexes were evaluated against the human colorectal cancer cell lines HT-29, HCT-116 p53+/+, HCT-116 p53?/? and ARPE-19 (non-cancer retinal epithelium).
Synthesis and selective cytotoxic activities on rhabdomyosarcoma and noncancerous cells of some heterocyclic chalcones
Do, Tuong-Ha,Nguyen, Dai-Minh,Truong, Van-Dat,Do, Thi-Hong-Tuoi,Le, Minh-Tri,Pham, Thanh-Quan,Thai, Khac-Minh,Tran, Thanh-Dao
, (2016/04/20)
Chemically diverse heterocyclic chalcones were prepared and evaluated for cytotoxicity, aiming to push forward potency and selectivity. They were tested against rhabdomyosarcoma (RMS) and noncancerous cell line (LLC-PK1). The influence of heteroaryl patte
