287720-98-3Relevant articles and documents
Synthesis and binding affinities of 4-diarylaminotropanes, a new class of delta opioid agonists
Boyd, Robert E.,Carson, John R.,Codd, Ellen E.,Gauthier, A. Diane,Neilson, Lou Anne,Zhang, Sui-Po
, p. 1109 - 1111 (2007/10/03)
A series of 4-diarylaminotropanes has been prepared. Both endo and exo diastereomeric forms bound to the delta opioid receptor but the endo isomers were more potent and selective versus the μ opioid receptor than the exo isomers. The most potent delta opioid agonist (14) exhibited a delta opioid K(i) of 0.2 nM and was 860-fold selective over mu. (C) 2000 Elsevier Science Ltd. All rights reserved.