28819-26-3

Basic information

• Product Name: 2-Pyridinepropanoic acid, Methyl ester
• Synonyms: 2-Pyridinepropanoic acid, Methyl ester;METHYL 3-(2-PYRIDYL)PROPANOATE
• CAS NO: 28819-26-3
• Molecular Formula: C₉H₁₁NO₂
• Molecular Weight: 165.18914
• Mol File: 28819-26-3.mol
• Article Data: 13

Chemical Properties

• Boiling Point: 235.8±15.0 °C(Predicted)
• Appearance: /
• Density: 1.086±0.06 g/cm3(Predicted)
• Storage Temp.: Inert atmosphere,Room Temperature
• PKA: 5.28±0.12(Predicted)
• CAS DataBase Reference: 2-Pyridinepropanoic acid, Methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Pyridinepropanoic acid, Methyl ester(28819-26-3)
• EPA Substance Registry System: 2-Pyridinepropanoic acid, Methyl ester(28819-26-3)

Safety Data

• Hazardous Substances Data: 28819-26-3(Hazardous Substances Data)

Usage

Description

2-Pyridinepropanoic acid, methyl ester is a chemical compound characterized by its molecular formula C8H9NO2. It is an ester of 2-pyridinepropanoic acid, known for its colorless, flammable liquid form with a distinctive fruity odor. This versatile chemical is recognized for its applications across various industries, including pharmaceuticals, agrochemicals, and the food and personal care sectors.

Uses

Used in Pharmaceutical and Agrochemical Industries:
2-Pyridinepropanoic acid, methyl ester is utilized as an intermediate in the synthesis of a range of pharmaceuticals and agrochemicals. Its role in these industries is pivotal for the development of new compounds with therapeutic or pesticidal properties.
Used in Flavoring Agents for the Food Industry:
In the food industry, 2-Pyridinepropanoic acid, methyl ester is employed as a flavoring agent. Its fruity aroma makes it a valuable component in enhancing the taste and smell of various food products.
Used in Fragrance Ingredients for Personal Care Products:
2-Pyridinepropanoic acid, methyl ester also serves as a fragrance ingredient in personal care products. Its pleasant scent contributes to the overall sensory experience of items such as perfumes, soaps, and lotions.

Upstream product

• 15197-75-8 3-(pyridin-2-yl)propanoic acid 
• 81124-45-0 (E)-3-(pyridin-2-yl)prop-2-enoic acid methyl ester 
• 67-56-1 methanol 
• 2057-32-1 3-(pyridin-2-yl)propanal 
• 292638-85-8 acrylic acid methyl ester 
• 2859-68-9 3-(pyridin-2-yl)-propanol 
• 865-33-8 potassium methanolate 
• 72764-93-3 methyl 3-(pyridin-2-yl)propiolate 
• 185990-03-8 dimethylphenyl(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)silane 
• 586-98-1 2-Hydroxymethylpyridine 
• 1121-60-4 pyridine-2-carbaldehyde 
• 54495-51-1 (E)-3-(2-pyridyl)acrylic acid 

Downstream Products

• 1027865-27-5 3-[2-Butyl-3-(2-chloro-benzyl)-3H-imidazol-4-yl]-3-hydroxy-2-pyridin-2-ylmethyl-propionic acid methyl ester 
• 143564-58-3 (E)-3-[2-Butyl-3-(2-chloro-benzyl)-3H-imidazol-4-yl]-2-pyridin-2-ylmethyl-acrylic acid 
• 1027139-42-9 (E)-3-[2-Butyl-3-(2-chloro-benzyl)-3H-imidazol-4-yl]-2-pyridin-2-ylmethyl-acrylic acid methyl ester 
• 2706-56-1 2-(aminoethyl)pyridine 
• 855184-57-5 (2-[2]pyridyl-ethyl)-carbamic acid methyl ester 

Relevant articles and documents

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Reduction of Electron-Deficient Alkenes Enabled by a Photoinduced Hydrogen Atom Transfer

Direct hydrogen atom transfer from a photoredox-generated Hantzsch ester radical cation to electron-deficient alkenes has enabled the development of an efficient formal hydrogenation under mild, operationally simple conditions. The HAT-driven mechanism is supported by experimental and computational studies. The reaction is applied to a variety of cinnamate derivatives and related structures, irrespective of the presence of electron-donating or electron-withdrawing substituents in the aromatic ring and with good functional group compatibility. (Figure presented.).

One and Two-Carbon Homologation of Primary and Secondary Alcohols to Corresponding Carboxylic Esters Using β-Carbonyl BT Sulfones as a Common Intermediate

Herein we report the efficient one- and two-carbon homologation of 1° and 2° alcohols to their corresponding homologated esters via the Mitsunobu reaction using β-carbonyl benzothiazole (BT) sulfone intermediates. The one-carbon homologation approach uses standard Mitsunobu C-S bond formation, oxidation and subsequent alkylation, while the two-carbon homologation uses a less common C-C bond forming Mitsunobu reaction. In this latter case, the use of β-BT sulfone bearing esters lowers the pKa sufficiently enough for the substrate to be used as a carbon-based nucleophile and deliver the homologated β-BT sulfone ester, and this superfluous sulfone group can then be cleaved. In this paper we describe several methods for the effective desulfonylation of BT sulfones and have developed methodology for one-pot alkylation-desulfonylation sequences. As such, overall, a one-carbon homologation sequence can be achieved in a two-pot (four step) procedure and the two-carbon homologation in a two-pot (three step) procedure (three-pot; four step when C-acid synthesis is included). This methodology has been applied to a wide variety of functionality (esters, silyl ethers, benzyls, heteroaryls, ketones, olefins and alkynes) and are all tolerated well providing good to very good overall yields. The power of our method was demonstrated in site-selective ingenol C20 allylic alcohol two-carbon homologation.