28824-94-4 Usage
General Description
5-methyl-2-phenyl-1H-imidazole-4-carboxylic acid is a chemical compound with the molecular formula C11H10N2O2. It is a derivative of imidazole, a five-membered heterocyclic ring containing two nitrogen atoms. 5-methyl-2-phenyl-1H-imidazole-4-carboxylic acid is used as a building block in the synthesis of pharmaceuticals and organic compounds. It has been found to exhibit potential antimicrobial and antifungal properties, making it potentially useful in the development of new drugs for combating infectious diseases. Its structure and reactivity make it a valuable intermediate in organic chemistry, allowing for the creation of diverse molecular structures with potential pharmaceutical applications.
Check Digit Verification of cas no
The CAS Registry Mumber 28824-94-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,8,8,2 and 4 respectively; the second part has 2 digits, 9 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 28824-94:
(7*2)+(6*8)+(5*8)+(4*2)+(3*4)+(2*9)+(1*4)=144
144 % 10 = 4
So 28824-94-4 is a valid CAS Registry Number.
InChI:InChI=1/C11H10N2O2/c1-7-9(11(14)15)13-10(12-7)8-5-3-2-4-6-8/h2-6H,1H3,(H,12,13)(H,14,15)
28824-94-4Relevant articles and documents
Discovery of cell-active phenyl-imidazole Pin1 inhibitors by structure-guided fragment evolution
Potter, Andrew,Oldfield, Victoria,Nunns, Claire,Fromont, Christophe,Ray, Stuart,Northfield, Christopher J.,Bryant, Christopher J.,Scrace, Simon F.,Robinson, David,Matossova, Natalia,Baker, Lisa,Dokurno, Pawel,Surgenor, Allan E.,Davis, Ben,Richardson, Christine M.,Murray, James B.,Moore, Jonathan D.
scheme or table, p. 6483 - 6488 (2010/12/18)
Pin1 is an emerging oncology target strongly implicated in Ras and ErbB2-mediated tumourigenesis. Pin1 isomerizes bonds linking phospho-serine/threonine moieties to proline enabling it to play a key role in proline-directed kinase signalling. Here we report a novel series of Pin1 inhibitors based on a phenyl imidazole acid core that contains sub-μM inhibitors. Compounds have been identified that block prostate cancer cell growth under conditions where Pin1 is essential.
