288399-99-5Relevant articles and documents
Synthesis and biological properties of new 1β-methylcarbapenems having tetrazolothioether moiety
Shin, Kye Jung,Koo, Ki Dong,Yoo, Kyung Ho,Kim, Dong Chan,Kim, Dong Jin,Park, Sang Woo
, p. 1421 - 1425 (2007/10/03)
The synthesis and biological activities of a series of new 1β-methylcarbapenems 1a-1 having tetrazolothioether moiety at C-5 position of pyrrolidine were described. Among these compounds, 1c showed the most potent antibacterial activity and advanced pharmacokinetics compared with imipenem and meropenem. (C) 2000 Elsevier Science Ltd. All rights reserved.