28843-40-5

Basic information

• Product Name: 7,8-METHYLENEDIOXY-6-METHOXYCOUMARIN
• Synonyms: 7,8-METHYLENEDIOXY-6-METHOXYCOUMARIN;4-Methoxy-8H-1,3-dioxolo[4,5-h][1]benzopyran-8-one;6-Methoxy-7,8-methylenedioxy-2H-1-benzopyran-2-one
• CAS NO: 28843-40-5
• Molecular Formula: C11H8O5
• Molecular Weight: 220.18
• Mol File: 28843-40-5.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 7,8-METHYLENEDIOXY-6-METHOXYCOUMARIN(CAS DataBase Reference)
• NIST Chemistry Reference: 7,8-METHYLENEDIOXY-6-METHOXYCOUMARIN(28843-40-5)
• EPA Substance Registry System: 7,8-METHYLENEDIOXY-6-METHOXYCOUMARIN(28843-40-5)

Safety Data

• Hazardous Substances Data: 28843-40-5(Hazardous Substances Data)

Upstream product

• 75-11-6 diiodomethane 
• 574-84-5 7,8-dihydroxy-6-methoxy-2H-1-benzopyran-2-one 
• 74-97-5 chlorobromomethane 
• 71765-80-5 6-methoxy-7-(3',3'-dimethylallyloxy)-8-hydroxycoumarin 
• 77369-04-1 obtusicin 

Relevant articles and documents

NEW COUMARINS OF Haplophyllum obtusifolium

Two coumarins have been isolated from an ethanolic extract of the epigeal part of Haplophyllum obtusifolium Lebed.: capensin (I) and the new coumarin obtusicin, C5H16O6, (II), mp 81-91 deg C (CH3OH).The acid hydrolysis of (I) and (II) leads to fraxetin.On the basis of the results of a study of acetylation products and the spectral characteristics (IR, UV, PMR, and mass spectra) it has been established that obtusician has the structure of 8-hydroxy-7-(4'-hydroxy-3'-methyl-but-2'-enyloxy)-6-methoxycoumarin.

A simple, high-yielding method for the methylenation of catechols

The methylenation of a variety of catechols is described, employing cesium carbonate and bromochloromethane in dimethylformamide at 110°C or acetonitrile at reflux. The corresponding methylenedioxy derivatives are obtained in 86-97 yield. Utilization of this method provided β-hydrastine in 70% yield from its corresponding dihydroxy analog.