28845-75-2 Usage
Description
2,2-Dibromo-2-(diethoxyphosphinyl)acetic acid ethyl ester, also known as Ethyl 2,2-Dibromodiethylphosphonoacetate, is an organic compound with a unique chemical structure that features a dibromoacetic acid core and a diethoxyphosphinyl group. This molecule is characterized by its potential reactivity and utility in various chemical processes due to its functional groups.
Uses
Used in Chemical Synthesis:
2,2-Dibromo-2-(diethoxyphosphinyl)acetic acid ethyl ester is used as a reagent for the synthesis of dialkylphosphonodibromoacetates and dialkylphosphonodibromoacetonitriles. These compounds are considered potential new biocides, which can be utilized in various industries for their antimicrobial and antifouling properties.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 2,2-Dibromo-2-(diethoxyphosphinyl)acetic acid ethyl ester serves as a coupling partner in Suzuki-Miyuara C-C bond formations. This reaction is a widely used method for the formation of carbon-carbon bonds, which is crucial in the synthesis of complex organic molecules, including potential drug candidates.
Check Digit Verification of cas no
The CAS Registry Mumber 28845-75-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,8,8,4 and 5 respectively; the second part has 2 digits, 7 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 28845-75:
(7*2)+(6*8)+(5*8)+(4*4)+(3*5)+(2*7)+(1*5)=152
152 % 10 = 2
So 28845-75-2 is a valid CAS Registry Number.
28845-75-2Relevant articles and documents
Visible-Light-Promoted Generation of α-Ketoradicals from Vinyl-bromides and Molecular Oxygen: Synthesis of Indenones and Dihydroindeno[1,2-c]chromenes
Pagire, Santosh K.,Kreitmeier, Peter,Reiser, Oliver
supporting information, p. 10928 - 10932 (2017/08/30)
Ortho-alkynylated α-bromocinnamates can be converted by a visible-light-mediated photocascade reaction with molecular oxygen into either indenones or dihydroindeno[1,2-c]chromenes. The one-step process features key photochemical steps, that is, the initial activation of vinyl bromides through energy transfer to give α-ketoradicals in a reaction with molecular oxygen, followed by α-oxidation of an arene moiety by 6-π electrocyclization, and subsequent hydroxylation by an electron-transfer process from the same photocatalyst leads to the dihydroindeno[1,2-c]chromenes.
A new general approach to 4-substituted-3-halo-2-quinolones
Zhao, Shuai,He, Yan-hong,Wu, Di,Guan, Zhi
experimental part, p. 597 - 605 (2010/06/21)
A general procedure for the preparation of 4-substituted-3-halo-2-quinolones (halo = F, Cl, Br) utilizing 2-halo diethylphosphonoacetic acids (halo = F, Cl, Br) and o-aminophenylketones as the starting materials is described. The title compounds are obtained by an intramolecular Horner-Wadsworth-Emmons olefination of halogen-containing N-acyl-o-aminophenylketones. The transformation process is generally applicable under mild conditions.