28892-73-1

Basic information

• Product Name: 3-hydroxy-2-methylvaleric acid
• Synonyms: 3-hydroxy-2-methylvaleric acid
• CAS NO: 28892-73-1
• Molecular Formula: C6H12O3
• Molecular Weight: 132.1577
• Mol File: 28892-73-1.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 250.5 °C at 760 mmHg
• Flash Point: 119.5 °C
• Appearance: /
• Density: 1.097 g/cm³
• Vapor Pressure: 0.00343mmHg at 25°C
• Refractive Index: 1.457
• CAS DataBase Reference: 3-hydroxy-2-methylvaleric acid(CAS DataBase Reference)
• NIST Chemistry Reference: 3-hydroxy-2-methylvaleric acid(28892-73-1)
• EPA Substance Registry System: 3-hydroxy-2-methylvaleric acid(28892-73-1)

Safety Data

• Hazardous Substances Data: 28892-73-1(Hazardous Substances Data)

Usage

General Description

3-Hydroxy-2-methylvaleric acid is a chemical compound that belongs to the class of organic compounds known as hydroxy fatty acids. It is an intermediate in the biosynthesis of the branched-chain fatty acid 3-hydroxy-2-methylbutyric acid, which is involved in the metabolism of the amino acid leucine. 3-Hydroxy-2-methylvaleric acid is also a metabolite of isobutyric acid, and it has the potential to act as a signaling molecule or a bioactive compound. 3-Hydroxy-2-methylvaleric acid has been studied for its potential therapeutic applications, including its role in various metabolic disorders and its effects on lipid metabolism and insulin sensitivity.

InChI:InChI=1/C6H12O3/c1-3-5(7)4(2)6(8)9/h4-5,7H,3H2,1-2H3,(H,8,9)

Upstream product

• 1424343-96-3 C₁₁H₁₆O₄ 
• 110793-80-1 (R)-5-But-3-enyl-dihydro-furan-2-one 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 10353-53-4 1,2-epoxy-5-hexene 
• 137688-20-1 (R)-2-(but-3-en-1-yl)oxirane 
• 1538-21-2 (3R^*,4R^*)-4-hydroxy-3-methylhexene 
• 119460-80-9 (4SR,5SR)-2,5-dihydroxy-2,4-dimethyl-2-O-trimethylsilylheptan-3-one 
• 123-38-6 propionaldehyde 
• 74-88-4 methyl iodide 
• 137033-02-4 (+/-)-3-hydroxy-2-methylenepentanoic acid 
• 802294-64-0 propionic acid 
• 133181-02-9 3-hydroxy-2-methylene-pentanoic acid methyl ester 
• 615-30-5 3-hydroxyl-2-methylpentanal 
• 121811-29-8 ethyl 2-methyl-3-oxopentanoate 

Downstream Products

• 96-22-0 pentan-3-one 
• 114607-20-4 1-ethylpropyl (2SR,3RS)-3-hydroxy-2-methylpentanoate 
• 115367-79-8 4-Ethyl-3-methyl-oxetan-2-one 
• 105-43-1 3-methylvaleric acid 
• 114607-20-4 2-Methyl-3-hydroxypentanoic acid threo-3-pentyl ester 
• 5145-01-7 3,5-dimethyldihydrofuran-2-one 

Relevant articles and documents

Process development of halaven: Synthesis of the C14-C35 fragment via iterative nozaki-hiyama-kishi reaction-williamson ether cyclization

Multikilogram manufacturing process of the Halaven C14-C35 fragment is described. The synthesis features convergent assembly of subunits by iterative asymmetric Ni/Cr-mediated coupling executed in fixed equipment. Georg Thieme Verlag Stuttgart - New York.

Diastereoselectivity in heterogeneous catalytic hydrogenation of Baylis-Hillman adducts. Total synthesis of (±)-sitophilate

We describe herein a highly diastereoselective total synthesis of racemic sitophilate, based on the results obtained in a diastereoselective heterogeneous catalytic hydrogenation reaction of a set of Baylis-Hillman adducts originating from aliphatic aldehydes.

SHORT SYNTHESIS OF RACEMIC SITOPHYLATE, THE AGGREGATION PHEROMONE OF A GRANARY WEEVIL

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