28899-75-4

Basic information

• Product Name: 7-chloro-1H-indole-2-carboxylic acid
• Synonyms: 7-chloro-1H-indole-2-carboxylic acid(SALTDATA: FREE);7-Chloroindole-2-carboxylic acid;1H-Indole-2-carboxylic acid, 7-chloro-
• CAS NO: 28899-75-4
• Molecular Formula: C₉H₆ClNO₂
• Molecular Weight: 195.61
• EINECS: 249-296-5
• Mol File: 28899-75-4.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 449.7°Cat760mmHg
• Flash Point: 225.8°C
• Appearance: /
• Density: 1.548g/cm³
• Vapor Pressure: 7.12E-09mmHg at 25°C
• Refractive Index: 1.728
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 4.23±0.30(Predicted)
• CAS DataBase Reference: 7-chloro-1H-indole-2-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 7-chloro-1H-indole-2-carboxylic acid(28899-75-4)
• EPA Substance Registry System: 7-chloro-1H-indole-2-carboxylic acid(28899-75-4)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 28899-75-4(Hazardous Substances Data)

Usage

General Description

7-chloro-1H-indole-2-carboxylic acid is a chemical compound with the molecular formula C9H6ClNO2. It is a derivative of indole, a heterocyclic aromatic organic compound. 7-chloro-1H-indole-2-carboxylic acid contains a chlorine atom and a carboxylic acid group attached to the indole ring, which gives it unique chemical properties and potential pharmaceutical applications. It is used in the synthesis of various pharmaceutical intermediates and can be used as a building block for the production of other indole-containing compounds. Additionally, it has been studied for its potential biological activities, such as anti-inflammatory and antiproliferative effects, making it a subject of interest in medicinal chemistry research.

InChI:InChI=1/C9H6ClNO2/c10-6-3-1-2-5-4-7(9(12)13)11-8(5)6/h1-4,11H,(H,12,13)

Upstream product

• 43142-64-9 7-Chloro-1H-indole-2-carboxylic acid ethyl ester 
• 77158-85-1 (3-chloro-2-nitro-phenyl)-pyruvic acid 
• 43142-70-7 ethyl (E)-2-(2-(2-chlorophenyl)hydrazono)propanoate 
• 41052-75-9 o-chlorophenylhydrazine hydrochloride 
• 115050-49-2 ethyl 2-[2-(2-chlorophenyl)hydrazinylidene]propanoate 

Downstream Products

• 53924-05-3 7-chloro-1H-indole 
• 1670-83-3 1H-Indole-7-carboxylic acid 
• 1473450-48-4 7-chloro-N-(cis-4-methylcyclohexyl)-1H-indole-2-carboxamide 
• 1473450-49-5 7-chloro-N-(trans-4-methylcyclohexyl)-1H-indole-2-carboxamide 
• 167479-16-5 1-methylindolyl-7-carboxylic acid 

Relevant articles and documents

Substituted indole - 2 - formic acid (by machine translation)

This invention relates to a substituted indole - 2 - carboxylic acid synthesis method, is to replace the phenyl hydrazine hydrochloride or arylhydrazines as raw materials, through with pyruvic acid ethyl ester cheng zong, Fischer indole synthesis by reaction of substituted indole - 2 - carboxylic acid ethyl ester, hydrolysis to obtain the substituted - 2 - carboxylic acid. Product purity is greater than 97%, the reaction yield is 64%. Synthesis method of the invention with non-harsh conditions, the operation is simple, and environmental friendliness, it has certain economic benefits. It is a kind of raw materials are easy, simple operation, three wastes, high yield of indole - 2 - carboxylic acid synthesis method. (by machine translation)

USE OF INDOLYL DERIVATIVES FOR THE MANUFACTURE OF A MEDICAMENT FOR THE TREATMENT ALLERGIC RHINITIS

A method to treat allergic rhinitis is disclosed in which patients are administered certain indolyl compounds.

Heterocyclic compounds

Heterocyclic compounds and methods of making them and using them.