28900-64-3 Usage
General Description
2,3-Dihydroxy-L-Phenylalanine, also known as L-DOPA, is a naturally occurring amino acid and chemical precursor in the synthesis of neurotransmitters dopamine, norepinephrine, and epinephrine. It is commonly used as a medication for the treatment of Parkinson's disease and dopamine-responsive dystonia due to its ability to cross the blood-brain barrier and be converted into dopamine. Additionally, it has been studied for its potential use in the treatment of depression, schizophrenia, and ADHD. L-DOPA can also be found in certain dietary sources such as broad beans and fava beans, as well as in the seeds and leaves of Mucuna pruriens, a tropical legume. Its chemical structure consists of a phenylalanine molecule with hydroxyl groups added to the 3 and 4 positions of the benzene ring, giving it its characteristic properties and biological activity.
Check Digit Verification of cas no
The CAS Registry Mumber 28900-64-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,8,9,0 and 0 respectively; the second part has 2 digits, 6 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 28900-64:
(7*2)+(6*8)+(5*9)+(4*0)+(3*0)+(2*6)+(1*4)=123
123 % 10 = 3
So 28900-64-3 is a valid CAS Registry Number.
28900-64-3Relevant articles and documents
Enantiomeric analysis of pharmaceutical compounds by Ion/molecule reactions
Grigorean,Lebrilla
, p. 1684 - 1691 (2007/10/03)
Protonated complexes involving cyclodextrin hosts and guest compounds that are pharmacologically important are produced in the gas phase and reacted with a gaseous amine. The guest is exchanged to produce a new protonated complex with the amine. The reaction is enantioselective and is used to develop a method for determining enantiomeric excess using only mass spectrometry. The pharmaceutical compounds include DOPA, amphetamine, ephedrine, and penicillamine. The presence of more than one reacting species is observed with DOPA and penicillamine. Molecular dynamics calculations are used to understand the nature of the interactions and the possible source of the variations in the reactivities.
