289039-82-3Relevant articles and documents
In situ catalytic generation of allylcopper species for asymmetric allylation: Toward 1H-isochromene skeletons
Kawai, Junya,Chikkade, Prasanna Kumara,Shimizu, Yohei,Kanai, Motomu
, p. 7177 - 7180 (2013)
Stay active: Allylcopper species can be generated in situ through catalytic intramolecular oxycupration of allenic alcohol. The allylcopper can react with various aldehydes and a ketone to give 1H-isochromene derivatives in an enantioselective manner (see scheme; HMPA=hexamethylphosphoramide, THF=tetrahydrofuran). The protocol is atom-economical, highly regioselective, stereoconvergent, and tolerant to free hydroxy groups. Copyright
ISOCHROMENE DERIVATIVES AS PHOSHOINOSITIDE 3-KINASES INHIBITORS
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Paragraph 0574; 0575; 0576, (2015/06/24)
Compounds of formula (I) described herein are useful for inhibiting phosphoinositide 3-kinases (PI3K) and the treatment of disorders associated with PI3K enzymes.
BENZO [C] ISOXAZOLOAZEPINE BROMODOMAIN INHIBITORS AND USES THEREOF
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Paragraph 00144; 00151; 00152, (2014/01/08)
The present invention relates to compounds useful as inhibitors of bromodomain- containing proteins. The invention also provides pharmaceutically acceptable compositions comprising compounds of the present invention and methods of using said compositions