28924-25-6

Basic information

• Product Name: 3,5-Dibenzyloxy terbutalline
• Synonyms: 1-[3,5-Bis(benzyloxy)phenyl]-2-(tert-butylamino)ethanol;3,5-Dibenzyloxy terbutalline;a-[[(1,1-Dimethylethyl)amino]methyl]-3,5-bis(phenylmethoxy)bnzenemethanol;Terbutaline 3,5-Dibenzyl Ether
• CAS NO: 28924-25-6
• Molecular Formula: C₂₆H₃₁NO₃
• Molecular Weight: 405.53
• Product Categories: Amines;Aromatics
• Mol File: 28924-25-6.mol
• Article Data: 4

Chemical Properties

• Melting Point: 124-126?C
• Appearance: /
• Density: 1.111
• Storage Temp.: Refrigerator
• Solubility: Chloroform
• CAS DataBase Reference: 3,5-Dibenzyloxy terbutalline(CAS DataBase Reference)
• NIST Chemistry Reference: 3,5-Dibenzyloxy terbutalline(28924-25-6)
• EPA Substance Registry System: 3,5-Dibenzyloxy terbutalline(28924-25-6)

Safety Data

• Hazardous Substances Data: 28924-25-6(Hazardous Substances Data)

Usage

Description

3,5-Dibenzyloxy terbutalline is an organic compound that serves as an intermediate in the preparation of Terbutaline, a medication used to treat asthma and other respiratory conditions. It is a white solid with specific chemical properties that make it a valuable component in the pharmaceutical industry.

Uses

Used in Pharmaceutical Industry:
3,5-Dibenzyloxy terbutalline is used as an intermediate for the preparation of Terbutaline, a medication that helps alleviate asthma symptoms and other respiratory issues. Its role in the synthesis process is crucial for producing an effective and widely-used drug for respiratory health.
As an intermediate, 3,5-Dibenzyloxy terbutalline contributes to the development of Terbutaline, which is known for its bronchodilating effects. This makes it an essential component in the pharmaceutical industry for creating medications that improve the quality of life for individuals suffering from respiratory conditions.

Upstream product

• 75-64-9 tert-butylamine 
• 100-39-0 benzyl bromide 
• 51863-60-6 3,5-dihydroxyacetophenone 
• 28924-21-2 3,5-dibenzyloxyacetophenone 
• 100-44-7 benzyl chloride 
• 50841-49-1 3,5-dibenzyloxyphenylglyoxal 

Downstream Products

• 23031-25-6 terbutaline 
• 23031-32-5 terbutaline hemisulfate 

Relevant articles and documents

Preparation method of terbutaline sulfate and B crystal form thereof

The invention relates to a preparation method of terbutaline sulfate and a B crystal form thereof, which comprises the following steps: sequentially carrying out bromination, reduction reaction and substitution reaction to obtain 1-[3, 5-bis (benzyloxy) phenyl]-2-(tert-butylamino) ethanol; reacting 1-[3, 5-di (benzyloxy) phenyl]-2-(tert-butylamino) ethanol with a reducing agent and a catalyst, performing salifying with sulfuric acid to obtain a terbutaline sulfate crude product, and crystallizing the terbutaline sulfate crude product under a heating reflux condition to obtain the terbutaline sulfate medicinal B crystal form. Raw materials and auxiliary materials used in the method are cheap and easy to obtain, highly toxic and explosive reagents are avoided in the reaction process, the whole reaction route is short, operation is easy and convenient, reaction conditions are mild and safe, the yield of the obtained finished product terbutaline sulfate and the medicinal B crystal form thereof is high, the yield of terbutaline sulfate is 83% or above, and the yield of the medicinal B crystal form is 70% or above, and industrialized production can be achieved easily.

Method for synthesizing terbutaline

The invention discloses a method for synthesizing terbutaline. The method comprises the following steps: reacting a compound I with selenium dioxide to obtain a compound II; reacting the compound II with tert-butylamine to obtain a compound III; reacting the compound III with a reducing agent to obtain a compound IV; and reacting the compound IV with a catalyst to remove benzyloxy to obtain terbutaline. The synthesis method has the advantage that the generation of impurity alpha-bromo-3, 5-dibenzyloxyacetophenone is avoided.