28945-95-1Relevant articles and documents
PREVENTIVE AND / OR THERAPEUTIC AGENTS FOR SIP-MEDIATED DISEASES
-
Paragraph 0214, (2021/04/22)
本發明之課題係提供一種將S1P5受體作動活性相對於S1P1受體作動活性之平衡經改善的化合物作為有效成份的醫藥組成物，以及將該醫藥組成物用於S1P5媒介疾病(例如，神經退化性疾病、多系統萎縮症、巴金森氏病)等之預防及/或治療的醫藥。 包含通式(V)(式中，各基的定義如說明書所載)所示之化合物或其藥學上可容許之鹽、及藥學上可容許之載體的醫藥組成物，係由於改善了S1P5受體作動活性相對於S1P1受體作動活性的平衡，故作為S1P5媒介疾病之預防及/或治療劑有用。 (式中，所有記號如說明書記載) An object
SUBSTITUTED 3,4-DIHYDRONAPHTHALENES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, AND PREPARATION PROCESSES
-
, (2008/06/13)
Substituted 3,4-dihydronaphthalenes of the formula I wherein R1 is a methyl or an amino group, R2 represents a hydrogen atom or a methyl group, and R3 is a linear or branched chain alkyl residue having 1 to 4 carbon atoms, an allyl or a crotyl group or a cyclopentyl group are disclosed which specifically inhibit 5-lipoxygenase and are useful in pharmaceutical compositions for prophylaxis and treatment of disorders attributable to the action of leucotrienes. The dihydronaphthalenes may be prepared by reacting a compound of formula II. with hydroxylamine or a salt thereof to form the corresponding oxime, reducing the oxime to a hydroxylamine of formula III and introducing a -CO-R1 group.
Chemotherapeutic nitro-heterocyclic compounds. 3. Preparation of nitrofurfurylidene-, nitrothenylidene- and nitropyrrolylmethylene-derivatives of substituted 1-indanones and 1.2.3.4-tetrahydro-1-naphthalenones
Albrecht,Schr?der
, p. 110 - 125 (2007/10/05)
-
