289636-10-8Relevant articles and documents
Synthesis and anti-platelet, anti-inflammatory and anti- allergic activities of methoxyisoflavanquinone and related compounds
Chang, Chiung-Yun,Huang, Li-Jiau,Wang, Jih-Pyang,Teng, Che-Ming,Chen, Sheng-Chih,Kuo, Sheng-Chu
, p. 964 - 973 (2007/10/03)
In a continuation of our search for novel anti-platelet agents, isoflavone quinone and isoflavanquinone were selected as lead compounds and the synthesis of their methoxy derivatives was carried out. Among them, the 4'- and 7-methoxy derivatives were successfully prepared, whereas the attempt to obtain 3'-methoxy derivatives resulted in their isomers, 3'-methoxyflavone quinone and 3'-methoxyflavanquinone, instead. After screening for their anti-platelet, anti-inflammatory and anti-allergic activities, a preliminary structure-activity relationship was established. Compounds 6c, 7a - c, 8c and 9a - c were found to exhibit significant activities. In particular, compound 7c demonstrated very potent anti-platelet, anti-inflammatory and anti-allergic activities and was then recommended for further pharmacological investigation.
