28989-52-8

Basic information

• Product Name: 4-(2-FURYL)-1,3-THIAZOL-2-AMINE
• Synonyms: 4-(furan-2-yl)-1,3-thiazol-2-amine;4-(2-FURYL)-1,3-THIAZOL-2-AMINE;4-FURAN-2-YL-THIAZOL-2-YLAMINE;IFLAB-BB F0863-0373;BUTTPARK 41\03-47;2-Thiazolamine, 4-(2-furanyl);2-AMino-4-(2-furyl)thiazole, 97%;4-(2-Furanyl)-2-thiazolamine
• CAS NO: 28989-52-8
• Molecular Formula: C7H6N2OS
• Molecular Weight: 166.2
• Mol File: 28989-52-8.mol
• Article Data: 16

Chemical Properties

• Melting Point: 126-127.0℃
• Boiling Point: 337.9±17.0 °C(Predicted)
• Appearance: Pale brown/Solid
• Density: 1.356
• Storage Temp.: 2-8°C
• PKA: 4.15±0.10(Predicted)
• CAS DataBase Reference: 4-(2-FURYL)-1,3-THIAZOL-2-AMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(2-FURYL)-1,3-THIAZOL-2-AMINE(28989-52-8)
• EPA Substance Registry System: 4-(2-FURYL)-1,3-THIAZOL-2-AMINE(28989-52-8)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• Hazardous Substances Data: 28989-52-8(Hazardous Substances Data)

Usage

General Description

4-(2-Furyl)-1,3-thiazol-2-amine, also known under its CAS Registry Number 185147-12-3, is a chemical compound. This specialty chemical falls under the categories of thiazoles, heterocyclic compounds, and, more broadly, organosulfurs. It has the chemical formula of C7H6N2OS. As denoted in the name, its basic structure includes a thiazole base, which is a 5-membered ring containing both sulfur and nitrogen, with a furyl group attached to the 4-position of the ring and an amine group attached to the 2-position. It has potential application in organic synthesis and pharmaceutical studies, although specific use-cases or details on its behavior and properties are limited in the public domain.

Upstream product

• 55984-17-3 2-chloroacetylfuran 
• 17356-08-0 thiourea 
• 15109-94-1 1-(2-furyl)-2-bromoethanone 
• 1192-62-7 1-(2-furyl)-1-ethanone 
• 80521-10-4 (tosyloxy)methyl 2-furanyl ketone 
• 492440-68-3 2-amino-5-bromo-4-(2-furyl)thiazole 
• 13331-23-2 fur-2-ylboronic acid 
• 502145-18-8 4-bromo-1,3-thiazol-2-amine 
• 527-69-5 2-furancarbonyl chloride 
• 55984-18-4 1-(furan-2-yl)-2-iodoethanone 

Downstream Products

• 75884-37-6 2-acetylamino-4-(2-furyl)thiazole 
• 83089-58-1 N-(4-Furan-2-yl-thiazol-2-yl)-oxalamic acid ethyl ester 

Relevant articles and documents

Thiocyanation, halogenation, dehalogenation, transhalogenation, and nitration of 2-substituted 4-(2-furyl)thiazoles

Bromination and thiocyanation of 2-amino- and 2-acetylamino-4-(2-furyl)thiazoles when 1 mol of reagent is used at 10°C are directed to the 5 position. Formation of 5′-bromo-substituted derivatives when the reaction temperature is raised is the result of a secondary, thermodynamically controlled process. Monohalogenation and mononitration of 4-(2-furyl)-2-methylthiazole are directed to the 5′ position. Nitration of 2-acetylamino-4-(5-nitro-2-furyl)thiazole by a nitrating mixture is accompanied by oxidative cleavage of the 5-nitrofuran moiety and leads to formation of 5,5′- and 3′,5′-dinitro derivatives.

Based on isoxazole substitution of benzamide derivatives and anti-prostate cancer drug applications

The present invention discloses a class (I), formula (II) structure based on isoxazole substituted benzamide derivatives and antiprostate cancer drug applications, such isoxazole substituted benzamide derivatives, can effectively inhibit the activity of a

Design and development of novel fasudil derivatives as potent antibreast cancer agent that improves intestinal flora and intestinal barrier function in rats

This study was conducted to develop novel fasudil derivatives after incorporation of substituted thiazoles as potent anti-breast cancer (BC) agents. The compounds were developed using a facile synthetic route in excellent yields. The entire set of developed compounds was tested for inhibitory activity against rho-associated coiled-coil kinase (ROCK; ROCK1 and ROCK2) kinase, where they exhibit potent and selective inhibition of ROCK1 as compared to ROCK2. The most potent ROCK2 inhibitor, compound 6h significantly inhibited the viability of BC cells (MCF-7). It also causes inhibition of migration and invasion of MCF-7 cells. Moreover, the anti-BC activity of compound 6h was studied in 7,12 dimethyl Benz(a)anthracene (DMBA)-induced BC in female Sprague Dawley rats. Results suggest that it causes significant improvement in the bodyweight of the animals with a reduction in oxidative stress in the liver and mammary tissues of rats. It showed improvement in the intestinal barrier function of rats by restoring the level of Diamine oxidase, d-lactate, and endotoxin. In western blot analysis, it showed improvement in (ZO-1), occludin, and claudin-1 in the colon tissue of the rat as compared to the DMBA group. Our study demonstrated the development of the novel class of fasudil derivatives potent anti-BC agent that improves intestinal flora and intestinal barrier function in rats.