28991-69-7

Basic information

• Product Name: 9H-Fluorene-9-methanol,phenylcarbamate(9CI)
• Synonyms: 9H-Fluorene-9-methanol,phenylcarbamate(9CI)
• CAS NO: 28991-69-7
• Molecular Formula: C₂₁H₁₇NO₂
• Molecular Weight: 0
• Product Categories: FMOC
• Mol File: 28991-69-7.mol
• Article Data: 10

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 9H-Fluorene-9-methanol,phenylcarbamate(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 9H-Fluorene-9-methanol,phenylcarbamate(9CI)(28991-69-7)
• EPA Substance Registry System: 9H-Fluorene-9-methanol,phenylcarbamate(9CI)(28991-69-7)

Safety Data

• Hazardous Substances Data: 28991-69-7(Hazardous Substances Data)

Upstream product

• 28920-43-6 (fluorenylmethoxy)carbonyl chloride 
• 62-53-3 aniline 
• 1001067-08-8 9-fluorenylmethyl 3-nitro-1H-1,2,4-triazole-1-carboxylate 
• 1202047-15-1 1-tert-butyl-1-ethyl-3-phenylurea 
• 24324-17-2 9-Fluorenylmethanol 
• 1346434-13-6 O-(9-fluorenylmethyl)-N-phenyl-N-chloromethyl carbamate 
• 1346434-14-7 (O-(N-((9-fluorenylmethoxy)carbonyl)-N-phenyl)aminomethyl)-N-(6-(2,4-dinitrophenyl)amino)hexanoyl-L-serine 
• 1346434-16-9 S-(N-(9-fluorenylmethoxycarbonyl-N-phenylamino)methyl)-N-(2,4-dinitrophenyl)-cysteine 
• 103-84-4 Acetanilid 
• 28920-44-7 (9H-fluoren-9-yl)methyl azidoformate 
• 98-80-6 phenylboronic acid 
• 82911-69-1 N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide 

Downstream Products

• 4425-82-5 9-methylene-fluorene 
• 501-82-6 N-phenylcarbamic acid 
• 2645-36-5 1-(N-phenylcarbamoyl)piperidine 
• 62-53-3 aniline 
• 1967-26-6 N-(4-chlorophenyl)-N'-phenylurea 

Relevant articles and documents

A greener, efficient and catalyst-free ultrasonic-assisted protocol for the n-fmoc protection of amines

A simple, eco-sustainable method for the N-(9-fluorenylmethoxycarbonyl) (N-Fmoc) protection of various structurally amines under ultrasonic irradiation is reported. The corresponding N-Fmoc derivatives were obtained in good to excellent yields within short reaction time. The reaction proceeds without the formation of any side product. Mildness, efficiency and easier work are the main advantages of this new protocol.

A synthetic approach to N -aryl carbamates via copper-catalyzed Chan-Lam coupling at room temperature

A mild and efficient synthesis of N-arylcarbamates was achieved by reacting azidoformates with boronic acids in the presence of 10 mol % of copper chloride catalyst. The reaction proceeds readily in an open flask at room temperature without additional base, ligand, or additive. Rapid access to urea analogues via a two-step one-pot procedure is enabled by reacting N-arylcarbamates with aluminum-amine complexes. In addition, among several boronic acid derivatives prepared, dimethylphenyl boronate was found to react rapidly in its reaction with benzyl azidoformate, invoking in situ generation of this species in the catalytic cycle.

Chemoselective N-deacetylation under mild conditions

A mild and efficient chemoselective N-deacetylation using the Schwartz reagent at room temperature in rapid time is described. The mild and neutral conditions enable orthogonal N-deacetylation in the presence of some of the common protecting groups (viz. Boc, Fmoc, Cbz, Ts). The deprotection conditions did not induce any epimerization at the chiral amino centre.