289910-68-5Relevant articles and documents
β-Casomorphins: Substitution of phenylalanine with β-homo phenylalanine increases the μ-type opioid receptor affinity
Longobardo, Luigi,Melck, Dominique,Siciliano, Rosa,Santini, Antonello,Marzo, Vincenzo Di,Cammarota, Giancarlo
, p. 1185 - 1188 (2007/10/03)
Two analogues of bovine β-casomorphin-7 and β-casomorphin-5 containing a β-homo phenylalanine in substitution of the phenylalanine in position 3 were synthesised and tested for their μ-opioid receptor affinity. The modification enhanced the μ receptor affinity 5-fold in the case of modified β-CM-7 and 2-fold for modified β-CM-5 when compared to the natural peptides. (C) 2000 Elsevier Science Ltd. All rights reserved.