289911-22-4

Basic information

• Product Name: (2-iodo-3-methoxy-5-methylphenyl)(1,4,8-trimethoxy-2-naphthyl)methanone
• Synonyms: (2-iodo-3-methoxy-5-methylphenyl)(1,4,8-trimethoxy-2-naphthyl)methanone
• CAS NO: 289911-22-4
• Molecular Weight: 492.31
• Mol File: 289911-22-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (2-iodo-3-methoxy-5-methylphenyl)(1,4,8-trimethoxy-2-naphthyl)methanone(CAS DataBase Reference)
• NIST Chemistry Reference: (2-iodo-3-methoxy-5-methylphenyl)(1,4,8-trimethoxy-2-naphthyl)methanone(289911-22-4)
• EPA Substance Registry System: (2-iodo-3-methoxy-5-methylphenyl)(1,4,8-trimethoxy-2-naphthyl)methanone(289911-22-4)

Safety Data

• Hazardous Substances Data: 289911-22-4(Hazardous Substances Data)

Upstream product

• 106116-42-1 1-bromomethyl-3-methoxy-5-methyl-benzene 
• 64636-39-1 1,4,5-Trimethoxynaphthalene 
• 4923-61-9 5-methoxynaphthoquinone 
• 874-63-5 3,5-dimethylmethoxybenzene 
• 95375-27-2 2-Bromo-1,4,8-trimethoxynaphthalene 
• 119650-45-2 (2-iodo-3-methoxy-5-methylphenyl)methanol 
• 199612-65-2 2-iodo-3-methoxy-5-methylbenzaldehyde 
• 69833-13-2 2-bromo-4,8-dimethoxynaphthalene-1-ol 

Relevant articles and documents

Annulation strategies for benzo[b]fluorene synthesis: efficient routes to the kinafluorenone and WS-5995 antibiotics.

Intramolecular palladium-mediated arylation approaches to benzo[b]fluorenes have been investigated. The methodology has been applied in a short synthesis of tri-O-methylkinafluorenone, providing an effective alternative to Friedel-Crafts-based approaches. During the course of this work, an acid-promoted quinolactonization of naphthoquinones was also developed, providing direct access to either ortho or para isomers as desired. Application of this methodology in syntheses of the antibiotics WS-5995A, WS-5995C, and functional analogues was demonstrated, and antitumoral activity of this class was determined.