2902-98-9Relevant articles and documents
3-AZABICYCLOOCTANE DERIVATIVES AS MUSCARINIC RECEPTOR ANTAGONISTS
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Page/Page column 7, (2009/05/28)
Provided are muscarinic receptor antagonists, which can be useful in treating various diseases of the respiratory, urinary and gastrointestinal systems mediated through muscarinic receptors. Also provided are processes for preparing compounds described herein, pharmaceutical compositions thereof, and methods for treating diseases mediated through muscarinic receptors.
PHOSPHORUS PENTACHLORIDE REACTIONS WITH CONJUGATED CARBONYL COMPOUNDS AND CONJUGATED OLEFINS
Duty, Robert C.,Farley, Thomas H.
, p. 271 - 280 (2007/10/02)
Phosphorus pentachloride was reacted with conjugated aromatic and carbonyl compounds.The conjugated aromatic compounds were cis and trans stilbene, and the carbonyl compounds were diphenylketene and 2,3,4,5-tetraphenylcyclopentadienone.Two solvents used for these reactions were 1,1,2,2-tetrachlorethane and methylene chloride.Phosphorus pentachloride can dissociate into phosphorus trichloride and chlorine and our results indicated this was the reaction mechanism for phosphorus pentachloride reacting with 2,3,4,5-tetraphenylcyclopentadienone.With stilbene, cis andtrans, the mechanism with phosphorus pentachloride was the sp3d2 octahedral complex mechanism.With diphenylketene the mechanism was the dissociation of phosphorus pentachloride into the phosphorus tetrachloro action and the phosphorus hexachloro anion.Key words: Phosphorus pentachloride, stilbene, diphenylketene, and 2,3,4,5-tetraphenylcyclopentadienone.
Diaryldichlorocarbonyl Ylides Derived from Dichlorocarbene and Aromatic Ketones
Martin, Charles W.,Gill, Harpal S.,Landgrebe, John A.
, p. 1898 - 1901 (2007/10/02)
The thermal decomposition of phenyl(bromodichloromethyl)mercury (4) in the presence of benzophenone (2) in dry benzene at 80 degC resulted in α-chlorodiphenylacetyl chloride (6) as the only major initial product together with small amounts of dichlorodiphenylmethane (5) and carbon monoxide.Analogous products were observed from fluorenone (3).Dimethyl acetylenedicarboxylate (15) failed to trap the presumed intermediate dihalocarbonyl ylide from either ketone.Attempts to explain the difference in behavior between dihalocarbonyl ylides derived from benzaldehydes and diaryl ketones suggest that in the latter case a twist in the plane of the ylide caused by endo,endo interactions of a chlorine and an aromatic ring leads to rapid closure to oxirane 11 followed by rearrangement to acid chloride 6.Alternative explanations are also explored.