290347-00-1

Basic information

• Product Name: (4S*)-N-[(R)-2-hydroxy-1-phenylethyl]-4-phenyl-1,2,3,4-tetrahydroisoquinoline
• Synonyms: (4S*)-N-[(R)-2-hydroxy-1-phenylethyl]-4-phenyl-1,2,3,4-tetrahydroisoquinoline
• CAS NO: 290347-00-1
• Molecular Weight: 329.442
• Mol File: 290347-00-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (4S*)-N-[(R)-2-hydroxy-1-phenylethyl]-4-phenyl-1,2,3,4-tetrahydroisoquinoline(CAS DataBase Reference)
• NIST Chemistry Reference: (4S*)-N-[(R)-2-hydroxy-1-phenylethyl]-4-phenyl-1,2,3,4-tetrahydroisoquinoline(290347-00-1)
• EPA Substance Registry System: (4S*)-N-[(R)-2-hydroxy-1-phenylethyl]-4-phenyl-1,2,3,4-tetrahydroisoquinoline(290347-00-1)

Safety Data

• Hazardous Substances Data: 290347-00-1(Hazardous Substances Data)

Upstream product

• 612-35-1 2-Benzylbenzoic acid 
• 290346-99-5 N-[(R)-2-hydroxy-1-phenylethyl]-4-phenyl-1,4-dihydroisoquinolin-3-one 
• 1586-00-1 2-(benzyl)benzyl alcohol 
• 5911-60-4 4-phenylisochroman-3-one 
• 290347-03-4 (4S*)-N-[(R)-2-hydroxy-1-phenylethyl]-4-phenyl-1,4-dihydroisoquinolin-3-one 

Downstream Products

• 153218-97-4 (4S)-(-)-4-phenyl-1,2,3,4-tetrahydroisoquinoline 
• 28102-51-4 (4S*)-N-methyl-4-phenyl-1,2,3,4-tetrahydroisoquinoline 

Relevant articles and documents

Diastereoselective protonation of lactam enolates derived from (R)-phenylglycinol. A novel asymmetric route to 4-phenyl-1,2,3,4-tetrahydroisoquinolines

(equation presented) Highly diastereoselective protonation of chiral lactam enolates of 4-substituted-1,4-dihydroisoquinolin-3-ones is reported. Protonation and alkylation processes of these lactam enolates derived from phenylglycinol occur with opposite diastereofacial selectivity. This diastereoselective protonation has been applied to the asymmetric synthesis of (4S)-N-methyl-4-phenyl-1,2,3,4-tetrahydroisoquinoline 9 obtained in up to 97% ee.