2905-67-1

Basic information

• Product Name: 3,5-DICHLOROBENZOIC ACID METHYL ESTER
• Synonyms: 3,5-DICHLOROBENZOIC ACID METHYL ESTER;METHYL 3,5-DICHLOROBENZOATE;BENZOIC ACID, 3,5-DICHLORO-, METHYL ESTER;BUTTPARK 45\07-94;RARECHEM AL BF 0057;Methyl 3,5-dichlorobenzoate 98%;Methyl 3,5- Dichlorobenzoate Standard;Methyl 3,5-dichlorobenzoate , Tech.
• CAS NO: 2905-67-1
• Molecular Formula: C₈H₆Cl₂O₂
• Molecular Weight: 205.04
• Product Categories: Aromatic Esters;Acids & Esters;Chlorine Compounds
• Mol File: 2905-67-1.mol
• Article Data: 9

Chemical Properties

• Melting Point: 56 °C
• Boiling Point: 273.4 °C at 760 mmHg
• Flash Point: 118.1 °C
• Appearance: /
• Density: 1.355 g/cm³
• Vapor Pressure: 0.00575mmHg at 25°C
• Refractive Index: 1.545
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 3,5-DICHLOROBENZOIC ACID METHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 3,5-DICHLOROBENZOIC ACID METHYL ESTER(2905-67-1)
• EPA Substance Registry System: 3,5-DICHLOROBENZOIC ACID METHYL ESTER(2905-67-1)

Safety Data

• Hazardous Substances Data: 2905-67-1(Hazardous Substances Data)

Usage

General Description

3,5-Dichlorobenzoic Acid Methyl Ester is a chemical compound often used in the field of organic synthesis. It's a derivative of benzoic acid, characterized by having two chlorine atoms and a methyl ester group attached to the benzene ring. Its molecular formula is C8H6Cl2O2. 3,5-DICHLOROBENZOIC ACID METHYL ESTER appears as a crystalline solid and is not naturally occurring. Potential hazards associated with this substance include skin and eye irritation as well as the potential to cause respiratory tract irritation. Like other chemicals, it should be handled with care following safety protocols.

InChI:InChI=1/C8H6Cl2O2/c1-12-8(11)5-2-6(9)4-7(10)3-5/h2-4H,1H3

Upstream product

• 186581-53-3 diazomethane 
• 51-36-5 3,5-dichlorobenzoic acid 
• 67-56-1 methanol 
• 2905-62-6 3,5-dichlorobenzoyl chloride 
• 17287-03-5 trimethylsulphonium hydroxide 
• 91085-56-2 3,5-dichlorobenzoic acid ethyl ester 
• 25186-47-4 3,5-dichlorotoluene 
• 18107-18-1 diazomethyl-trimethyl-silane 
• 10203-08-4 3,5-dichlorobenzaldehyde 

Downstream Products

• 68575-36-0 1,3-dichloro-5-(prop-1-en-2-yl)benzene 
• 60211-57-6 3,5-dichlorobenzyl alcohol 
• 33244-92-7 3,5-dichloro-N-methylbenzamide 
• 327056-71-3 3-chloro-5-cyanobenzoic acid 
• 943436-52-0 1-(3,5-dichlorophenyl)-2,2,2-trifluoro-1-trimethylsilyloxy-1-methoxyethane 
• 2905-65-9 methyl 3-chlorobenzoate 
• 1211800-73-5 C₁₃H₁₆BClO₄ 
• 1192765-28-8 methyl 3,5-bis(5,5-dimethyl-1,3,2-dioxaborinan-2-yl)benzoate 
• 924887-13-8 C₂₀H₁₄Cl₂O₃ 
• 569328-84-3 (5-chloro-3-methoxymethyl-2-nitrophenyl)(4,6-dimethoxypyrimidin-2-yl)acetonitrile 
• 569328-81-0 (5-chloro-3-methoxymethyl-2-nitrophenyl)(4,6-dimethoxypyrimidin-2-yl)ketone 
• 1267952-23-7 2,4-dichloro-6-methoxymethylnitrobenzene 
• 1267952-21-5 2,4-dichloro-6-hydroxymethylnitrobenzene 
• 845781-25-1 1-(3,5-dichlorophenyl)-2-phenylethan-1-one 

Relevant articles and documents

The effect of indium(III) triflate in oxone-mediated oxidative methyl esterification of aldehydes

An oxidative methyl esterification of aldehydes was effectively achieved. The trivalent indium reagent, indium(III) triflate, was revealed to accelerate the reactions in many cases. Aromatic aldehydes with various substituents were subjected to this method, and each produced the corresponding methyl esters in good to excellent yields within a relatively short reaction time.

Electroreduction of organic compounds, 36 [1]. Electroreduction of chlorinated methyl benzoates

The preparative electroreduction of the three methyl monochlorobenzoates, the six methyl dichlorobenzoates, and methyl 2,3,4-trichlorobenzoate in different solvent-supporting electrolytes (SSE) was studied. The rate of the dechlorination, which is the main reaction, is dependent on the substitution pattern. Pronounced regioselectivity is therefore observed in case of the oligochloro derivatives. Hydrogenation of the benzene ring and reduction of the methoxycarbonyl group with formation of a hydroxymethyl group are observed as side-reactions. Quantum chemical calculations on the reaction mechanism were performed. The theoretical results are in accordance with the experimental observations.

DIARYLTRIAZOLES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE-1

2,5-Diaryl-1,2,4-triazole derivatives of structural formula I are selective inhibitors of the 11β-hydroxysteroiddehydrogenase Type 1 enzyme (11β-HSD-1). The compounds are useful for the treatment of diabetes, hyperglycemia, obesity,insulin resistance, atherosclerosis, dyslipidemia, hyperlipidemia, hypertension, and Metabolic Syndrome. Also disclosed are novel compounds of structural formula II which are inhibitors of 11β-HSD-1