29054-08-8 Usage
Description
2-METHYL-D3-PROPIONIC-3,3,3-D3 ACID, also known as Isobutyric-d6 Acid, is an isotope-labeled analogue of Isobutyric Acid, a carboxylic acid found in vanilla. It is characterized by its unique isotopic composition, which distinguishes it from its non-labeled counterpart. This property makes it a valuable tool in various scientific and industrial applications, particularly in the field of research and development.
Uses
Used in Pharmaceutical Industry:
2-METHYL-D3-PROPIONIC-3,3,3-D3 ACID is used as an intermediate in the synthesis of novel inhibitors for the signal transducer and activators of transcription 3 (STAT3) signaling pathway. This application is significant because the STAT3 pathway plays a crucial role in various cellular processes, including cell growth, differentiation, and apoptosis. Modulating this pathway can lead to the development of new therapeutic strategies for a range of diseases, including cancer and autoimmune disorders.
Used in Research and Development:
In the field of research and development, 2-METHYL-D3-PROPIONIC-3,3,3-D3 ACID serves as a valuable tool for studying the mechanisms of various biological processes. Its isotopic labeling allows researchers to track and monitor the behavior of molecules in complex biological systems, providing insights into the underlying molecular interactions and pathways. This information can be instrumental in the design and development of new drugs and therapies.
Used in Analytical Chemistry:
2-METHYL-D3-PROPIONIC-3,3,3-D3 ACID can be employed as a labeled internal standard in analytical chemistry, particularly in mass spectrometry and nuclear magnetic resonance (NMR) spectroscopy. Its isotopic composition provides a unique signature that can be used to accurately quantify and identify target molecules in complex samples, such as biological tissues and environmental samples. This application is essential for ensuring the accuracy and reliability of analytical results in various fields, including drug development, environmental monitoring, and forensic science.
Used in Chemical Synthesis:
In addition to its applications in the pharmaceutical industry, 2-METHYL-D3-PROPIONIC-3,3,3-D3 ACID can also be used as a building block in the synthesis of various organic compounds. Its unique isotopic composition can be exploited to create novel molecules with specific properties, such as enhanced stability, improved bioavailability, or altered biological activity. This makes it a valuable resource for the development of new materials and compounds with potential applications in various industries, including pharmaceuticals, agriculture, and materials science.
Check Digit Verification of cas no
The CAS Registry Mumber 29054-08-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,9,0,5 and 4 respectively; the second part has 2 digits, 0 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 29054-08:
(7*2)+(6*9)+(5*0)+(4*5)+(3*4)+(2*0)+(1*8)=108
108 % 10 = 8
So 29054-08-8 is a valid CAS Registry Number.
29054-08-8Relevant articles and documents
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Dunn,Warkentin
, p. 75,79 (1956)
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Isobutyric acid D7 synthesis method and isobutyric acid D6 synthesis method
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Paragraph 0017, (2020/04/17)
The invention provides an isobutyric acid D7 synthesis method. The isobutyric acid D7 synthesis method comprises the following steps of: taking 2-bromopropane-D7, magnesium and carbon dioxide as raw materials, and carrying out Grignard reaction to prepare a compound isobutyric acid D7. The invention also provides a isobutyric acid D6 synthesis method. The isobutyric acid D6 synthesis method comprises the following steps of: taking isobutyric acid-D7 and water as raw materials, and preparing the compound isobutyric acid D6 under an alkaline condition. According to the isobutyric acid D7 synthesis method and the isobutyric acid D6 synthesis method, 2-bromopropane-D7 which can be directly purchased and is moderate in price is directly used as the raw material, the isobutyric acid D7 is directly synthesized through Grignard reaction, the synthesis steps are short, the yield is 71%, hydrogen and deuterium exchange is adopted when the isobutyric acid D7 is used for synthesizing the isobutyric acid D6, the route is short, and the yield is 78.6%.
Substituted pyridazinone compound
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Paragraph 0161; 0164; 0169-0170, (2019/04/17)
The invention provides a pharmaceutical composition of a substituted pyridazinone compound, and application thereof. The substituted pyridazinone compound is a compound as shown in formula (I), or a pharmaceutically acceptable salt, prodrug, hydrate or solvent compound, crystalline form, stereoisomer or isotopic variant thereof. The compound, namely a THR-beta agonist, can be used for treating and/or preventing diseases regulated by thyroid hormone analogs.
