29070-92-6 Usage
Description
Pachymic acid (PA) is a lanostane-type triterpenoid derived from Poriacocos, a component of traditional Chinese medicine. It is known for its anti-emetic, anti-inflammatory, and anticancer properties, as well as its ability to inhibit the phospholipase A2 (PLA2) family of enzymes, which produce arachidonic acid.
Uses
Used in Anticancer Applications:
Pachymic acid is used as an anticancer agent for its ability to inhibit cell growth, modulate arachidonic acid metabolism, and impair cancer cell invasion. It achieves this by suppressing various signaling pathways, such as MAPKs and NF-kappaB, and by initiating apoptosis through mitochondrial dysfunction and the reduction of prostaglandin.
Used in Inflammation and Oral Disease Prevention:
Pachymic acid is used as an anti-inflammatory agent to prevent complications of oral diseases, such as inflammation and alveolar destruction of the oral cavity. It exhibits antioxidant activity, affects the removal of reactive oxygen species, and inhibits nuclear factor-κB translocation.
Used in Pancreatic Cancer Treatment:
Pachymic acid is used as a treatment for pancreatic cancer by suppressing the invasiveness of pancreatic cancer cells through the downregulation of MMP-7.
Used in Lung Cancer Treatment:
Pachymic acid is used as a treatment for lung cancer by activating reactive oxygen species (ROS)-dependent JUN N-terminal kinase mitochondrial and endoplasmic reticulum stress pathways, leading to cell cycle arrest at the G2/M phase and cell apoptosis.
Used in Prostate Cancer Treatment:
Pachymic acid is used as a treatment for prostate cancer by reducing proliferation and inducing apoptosis through the inactivation of AKT signaling and downregulation of AKT downstream protein expression.
Used in Enhancing Glucose Uptake:
Pachymic acid is used to stimulate glucose uptake by enhancing the expression and translocation of glucose transporter type 4.
Note: The therapeutic effects and potential mechanisms of PA on gastric cancer are not well understood and require further evaluation.
Anticancer Research
Extracted from Poria cocos, pachymic acid (PA) is a tri-terpenoid (a lanostanetype), which is reported to have anticancerous properties. NCI-H460 and NCI-H23cells, the lung cancer cell lines, were studied for the effect of pachymic acid.Expression of a major UPR target gene-regulated protein, CHOP, was upregulatedresulting in cell apoptosis after PA treatment. It was discovered that ROS inhibitorsblocked the ER stress activation induced by PA. The results indicated that ROSproduction is also regulated by PA in lung cancer cells (Cheng et al. 2015; Jun et al.2015). As per the studies conducted on MIA PaCa-2 and PANC-1 cell lines,PA-induced apoptosis in pancreatic cancer cell resistant to gemcitabine wasdependent on in vivo and in vitro activation of ER stress. PA can be exploited for itsanticancer effects for treatment of pancreatic cancer resistant to chemotherapy(Cheng et al. 2015).
Check Digit Verification of cas no
The CAS Registry Mumber 29070-92-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,9,0,7 and 0 respectively; the second part has 2 digits, 9 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 29070-92:
(7*2)+(6*9)+(5*0)+(4*7)+(3*0)+(2*9)+(1*2)=116
116 % 10 = 6
So 29070-92-6 is a valid CAS Registry Number.
InChI:InChI=1/C33H52O5/c1-19(2)20(3)10-11-22(29(36)37)28-25(35)18-33(9)24-12-13-26-30(5,6)27(38-21(4)34)15-16-31(26,7)23(24)14-17-32(28,33)8/h19,22,25-28,35H,3,10-18H2,1-2,4-9H3,(H,36,37)/t22-,25-,26+,27+,28+,31-,32-,33+/m1/s1
