2908-60-3Relevant articles and documents
Discovery of 4-Hydroxy-3-(3-(phenylureido)benzenesulfonamides as SLC-0111 Analogues for the Treatment of Hypoxic Tumors Overexpressing Carbonic Anhydrase IX
Bozdag, Murat,Carta, Fabrizio,Ceruso, Mariangela,Ferraroni, Marta,McDonald, Paul C.,Dedhar, Shoukat,Supuran, Claudiu T.
, p. 6328 - 6338 (2018)
Herein we report the 2-aminophenol-4-sulfonamide 1 and its ureido derivatives 2-23 as inhibitors of the carbonic anhydrase (CA, EC 4.2.1.1) enzymes as analogues of the hypoxic tumor phase II entering drug SLC-0111. This scaffold may determine preferential