290835-51-7

Basic information

• Product Name: 5-(4-chlorobenzyl)thiazol-2-aMine
• Synonyms: 5-(4-chlorobenzyl)thiazol-2-aMine;5-[(4-chlorophenyl)methyl]thiazol-2-amine
• CAS NO: 290835-51-7
• Molecular Formula: C₁₀H₉ClN₂S
• Molecular Weight: 224.70986
• EINECS: -0
• Mol File: 290835-51-7.mol
• Article Data: 10

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 5-(4-chlorobenzyl)thiazol-2-aMine(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(4-chlorobenzyl)thiazol-2-aMine(290835-51-7)
• EPA Substance Registry System: 5-(4-chlorobenzyl)thiazol-2-aMine(290835-51-7)

Safety Data

• Hazardous Substances Data: 290835-51-7(Hazardous Substances Data)

Usage

General Description

5-(4-chlorobenzyl)thiazol-2-amine is a chemical compound with the molecular formula C10H9ClN2S. It belongs to the thiazole class of compounds and contains a thiazole ring that is substituted with a chlorobenzyl group at the 5-position and an amine group at the 2-position. This chemical is known for its potential use in pharmaceutical research and drug discovery, particularly in the development of new antibiotics and antimicrobial agents. It may also have applications in the field of agrochemicals and material science. The compound's structure and properties make it of interest for further investigation and potential development for various practical and commercial purposes.

Upstream product

• 99846-92-1 2-chloro-3-(4-chlorophenyl)propanal 
• 17356-08-0 thiourea 
• 2028-74-2 p-chlorobenzenediazonium chloride 
• 106-47-8 4-chloro-aniline 

Downstream Products

• 924824-35-1 N-[5-(4-chlorobenzyl)-1,3-thiazol-2-yl]chromane-3-carboxamide 
• 1200399-18-3 1,1-dimethylethyl 6-[({5-[(4-chlorophenyl)methyl]-1,3-thiazol-2-yl}amino)carbonyl]-3,4-dihydro-2(1H)-isoquinolinecarboxylate 
• 1208553-00-7 C₂₂H₂₂Cl₂N₂OS 
• 862265-00-7 C₁₃H₁₂Cl₂N₂OS 
• 301306-14-9 2-chloro-N-[5-[(4-chlorophenyl)methyl]thiazol-2-yl]acetamide 
• 1353638-26-2 C₁₃H₁₀ClN₃OS₂ 
• 1200399-64-9 N-{5-[(4-chlorophenyl)methyl]-1,3-thiazol-2-yl}-1,2,3,4-tetrahydro-6-isoquinolinecarboxamide hydrochloride 

Relevant articles and documents

Synthesis and BK channel-opening activity of 2-amino-1,3-thiazole derivatives

A series of 2-amino-5-arylmethyl- or 5-heteroarylmethyl-1,3-thiazole derivatives were synthesized and evaluated for BK channel-opening activities in cell-based fluorescence assay and electrophysiological recording. The assay results indicated that the activities of the investigated compounds were influenced by the physicochemical properties of the substituent at benzene ring.

Glucose promoted facile reduction of azides to amines under aqueous alkaline conditions

A quick and efficient method for the reduction of azides to amines in water using d-glucose and KOH as green reagents is reported. The protocol is simple, inexpensive, scalable, and can be applied to different aromatic, heteroaromatic and sulphonyl azides. A high level of chemoselectivity is observed for azide reduction in the presence of other reducible functionalities like cyano, nitro, ether, ketone, amide and acid. The reaction gets completed in a short time (5-20 minutes), and furnishes the amines in high yield (85-99%). Unlike conventional hydrogenations, this reduction protocol does not require any metal catalyst, elaborate experimental setup or use of high-pressure equipment.

A convenient method for the synthesis of 2-[(5-benzyl-1,3-thiazol-2-yl) imino]-1,3-thiazolidin-4-one derivatives

It was found that the reaction of 2-chloroacetamido/chloropropioamido-5- benzylthiazole with potassium thiocyanate gave, via rearrangement, 2-[(5-benzyl-1,3-thiazol-2-yl)imino]-1,3-thiazolidin-4-ones.