290836-37-2Relevant articles and documents
Synthesis of α-amino-α′, α′-dihaloketones and process for the preparation of β-amino acid derivatives by the use of the same
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, (2008/06/13)
The present invention provides a commercially profitable process for producing a β-amino acid ester derivative which comprises reacting an α-amino acid ester derivative with a base and a dihalomethane, reacting the same with a lithium amide and an alkylli
Dihalomethylation of N-protected phenylalanine esters
Onishi, Tomoyuki,Otake, Yasuyuki,Hirose, Naoko,Nakano, Takashi,Torii, Takayoshi,Nakazawa, Masakazu,Izawa, Kunisuke
, p. 6337 - 6340 (2007/10/03)
Dihalomethylation of several N-protected amino acid esters gave N-protected α-aminoalkyl-α′-dihalomethylketones, which are useful intermediates for the synthesis of erythro β-amino-α-hydroxycarboxylic acids, in good yield. The dihalomethylketones were successfully converted to N-protected α-aminoalkyl-α′-halomethylketones by selective catalytic hydrogenation.
