29096-75-1Relevant articles and documents
Potentiation of Francisella resistance to conventional antibiotics through small molecule adjuvants
Stephens, Matthew D.,Hubble, Veroncia B.,Ernst, Robert K.,Van Hoek, Monique L.,Melander, Roberta J.,Cavanagh, John,Melander, Christian
, p. 128 - 131 (2016)
A screen of 20 compounds identified small molecule adjuvants capable of potentiating antibiotic activity against Francisella philomiragia. Analogue synthesis of an initial hit compound led to the discovery of a potentially new class of small molecule adjuvants containing an indole core. The lead compound was able to lower the MIC of colistin by 32-fold against intrinsically resistant F. philomiragia.
Cu-Catalyzed Synthesis of 3-Formyl Imidazo[1,2-a]pyridines and Imidazo[1,2-a]pyrimidines by Employing Ethyl Tertiary Amines as Carbon Sources
Rao, Changqing,Mai, Shaoyu,Song, Qiuling
supporting information, p. 4726 - 4729 (2017/09/22)
A highly efficient synthesis of 3-formyl imidazo[1,2-a]pyridine and imidazo[1,2-a]pyrimidine, under Cu-catalyzed aerobic oxidative conditions and by utilizing ethyl tertiary amines as carbon sources, is disclosed. A novel activation mode of ethyl tertiary amines in which simultaneous selective cleavage of C-C bond and C-N bond of ethyl group with molecular oxygen as terminal oxidant in this one-pot protocol is reported for the first time. This reaction features broad substrate scope, good functional group tolerance, as well as diversified and valuable products.
2-aminobenzimidazole derivatives strongly inhibit and disperse Pseudomonas aeruginosa biofilms
Frei, Reto,Breitbach, Anthony S.,Blackwell, Helen E.
supporting information; experimental part, p. 5226 - 5229 (2012/07/03)
Bacterial biofilms are exceptionally difficult to clear using traditional antibiotics and constitute a significant health threat. 2-Aminobenzimidazole derivatives (see scheme) are capable of strongly inhibiting the growth of and dispersing Pseudomonas aeruginosa biofilms. These molecules were found to modulate quorum sensing in reporter strains, and represent some of strongest P. aeruginosa biofilm inhibitors known. Copyright