29108-89-2

Basic information

• Product Name: 3',5'-dideoxythymidine
• Synonyms: 3',5'-dideoxythymidine
• CAS NO: 29108-89-2
• Molecular Formula: C₁₀H₁₄N₂O₃
• Molecular Weight: 210.22976
• Mol File: 29108-89-2.mol
• Article Data: 1

Chemical Properties

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Appearance: /
• Density: 1.227g/cm³
• Refractive Index: 1.528
• CAS DataBase Reference: 3',5'-dideoxythymidine(CAS DataBase Reference)
• NIST Chemistry Reference: 3',5'-dideoxythymidine(29108-89-2)
• EPA Substance Registry System: 3',5'-dideoxythymidine(29108-89-2)

Safety Data

• Hazardous Substances Data: 29108-89-2(Hazardous Substances Data)

Usage

InChI:InChI=1/C10H14N2O3/c1-6-5-12(10(14)11-9(6)13)8-4-3-7(2)15-8/h5,7-8H,3-4H2,1-2H3,(H,11,13,14)

Upstream product

• 60762-71-2 1-((2R)-5c-bromomethyl-tetrahydro-[2r]furyl)-5-methyl-1H-pyrimidine-2,4-dione 
• 123884-07-1 3',5'-bis-O-(phenoxythiocarbonyl)thymidine 
• 50-89-5 thymidine 
• 34627-69-5 1-((2R)-3c-bromo-5c-bromomethyl-tetrahydro-furan-2r-yl)-methyl-1H-pyrimidine-2,4-dione 
• 56822-33-4 3',5'-di-O-mesylthymidine 

Relevant articles and documents

Facile Synthesis of 3'-O-Methylthymidine and 3'-Deoxythymidine and Related Deoxygenated Thymidine Derivative: A New Method for Selective Deoxygenation of Secondary Hydroxy Groups

This paper deals with convenient synthesis of 3'-O-methylthymidine (2) and 3'-deoxythymidine (3), which involve Ag2O-promoted methylation and Barton-Robins reductive deoxygenation, respectively.New methods for the regioselective 3'- and 5'-deoxygenation of thymidine have also been developed.Namely, compound 3 was synthesized by the 3',5'-O-diacylation of thymidine with phenyl chlorothionoformate (PTCF) followed by the selective 3'-reduction with tributyltin hydride and successive alkaline hydrolysis. 5'-Deoxythymidine (18) was obtained by the 5'-selective acylation of thymidine with PTCF followed by reduction with tributyltin hydride.