2912-78-9 Usage
Description
2-Hydroxy-5-nitrobenzamide is an organic compound with the molecular formula C7H6N2O4. It is characterized by the presence of a hydroxyl group at the 2nd position and a nitro group at the 5th position of the benzene ring, with an amide functional group attached. 2-hydroxy-5-nitrobenzamide is known for its potential applications in various chemical and pharmaceutical processes due to its unique structural features.
Uses
Used in Pharmaceutical Industry:
2-Hydroxy-5-nitrobenzamide is used as an intermediate in the synthesis of salicylamides and its nitro derivatives. These compounds have potential applications in the development of new drugs, particularly those targeting pain relief and inflammation. The presence of the hydroxyl and nitro groups in the molecule allows for further chemical modifications, enabling the creation of a diverse range of pharmaceutically active compounds.
Used in Chemical Synthesis:
In the field of organic chemistry, 2-hydroxy-5-nitrobenzamide serves as a versatile building block for the synthesis of various complex organic molecules. Its unique structural features, including the hydroxyl and nitro groups, make it a valuable precursor for the development of novel chemical entities with potential applications in various industries, such as materials science, agrochemicals, and pharmaceuticals.
Check Digit Verification of cas no
The CAS Registry Mumber 2912-78-9 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 2,9,1 and 2 respectively; the second part has 2 digits, 7 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 2912-78:
(6*2)+(5*9)+(4*1)+(3*2)+(2*7)+(1*8)=89
89 % 10 = 9
So 2912-78-9 is a valid CAS Registry Number.
InChI:InChI=1/C7H6N2O4/c8-7(11)5-3-4(9(12)13)1-2-6(5)10/h1-3,10H,(H2,8,11)
2912-78-9Relevant articles and documents
Acid Catalyzed Direct-Amidation-Dehydrocyclization of 2-Hydroxy-acetophenones to Benzoxazoles by a One-Pot Sustainable Synthesis
Rancan, Elia,Aric, Fabio,Quartarone, Giuseppe,Ronchin, Lucio,Vavasori, Andrea
, p. 939 - 946 (2015/08/06)
A series of 2-methyl-benzoxazoles have been synthesized starting from 2-hydroxy-acetophenones via a one-pot three steps reaction. Hydroxylamonium salt has been used as amidation agent. The reaction occurs with different anions, but the best results is achieved with hydroxylamonium hydrchloride. Despite the number of consecutive stages, the reaction is highly selective. Mild reaction conditions and various solvents can be used, but trifluoroacetic acid is the preferred. Almost, complete recovery of the trifluoroacetic acid can be achieved by vacuum distillation. The role of trifluoroacetic acid, as well as, of the hydroxylamonium salt suggests a cooperative effect leading to high selective formation of 2-methyl-benzoxazoles. Graphical Abstract: One-pot TFA catalyzed synthesis of benzoxazoles starting from 2-hydroxyacetophenones. (Chemical Equation Presented).
Substrate-assisted catalysis in glycosidases
Wang, Qingping,Withers, Stephen G.
, p. 10137 - 10138 (2007/10/02)
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