29206-06-2

Basic information

• Product Name: 4-Methoxy-a,a-dimethylbenzenepropanoic acid
• Synonyms: 4-Methoxy-a,a-dimethylbenzenepropanoic acid;3-(4-methoxyphenyl)-2,2-dimethylpropanoic acid;3-(4-Methoxyphenyl)-2,2-dimethylpropionic acid
• CAS NO: 29206-06-2
• Molecular Formula: C₁₂H₁₆O₃
• Molecular Weight: 208.26
• Mol File: 29206-06-2.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-Methoxy-a,a-dimethylbenzenepropanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Methoxy-a,a-dimethylbenzenepropanoic acid(29206-06-2)
• EPA Substance Registry System: 4-Methoxy-a,a-dimethylbenzenepropanoic acid(29206-06-2)

Safety Data

• Hazardous Substances Data: 29206-06-2(Hazardous Substances Data)

Usage

Description

4-Methoxy-a,a-dimethylbenzenepropanoic acid, also known as 2,2-Dimethyl-3-(4-methoxyphenyl)propanoic acid, is an organic compound with a unique chemical structure that features a benzene ring and a propanoic acid group. It is characterized by its molecular formula C11H14O3 and has potential applications in various fields due to its chemical properties.

Uses

Used in Pharmaceutical Industry:
4-Methoxy-a,a-dimethylbenzenepropanoic acid is used as an intermediate in the synthesis of various pharmaceutical compounds. Its unique structure allows it to be a key component in the development of new drugs with specific therapeutic properties.
Used in Biological Studies:
4-Methoxy-a,a-dimethylbenzenepropanoic acid is used in biological studies to analyze the effects of certain hallucinogenic amphetamine analogs on the release of [3H]-serotonin from rat brain synaptosomes. This application helps researchers understand the interaction between the compound and neurotransmitter systems, which can be crucial for developing treatments for neurological and psychiatric disorders.
Used in Chemical Research:
4-Methoxy-a,a-dimethylbenzenepropanoic acid can also be used in chemical research as a starting material for the synthesis of various organic compounds. Its versatile structure makes it a valuable tool for exploring new chemical reactions and developing novel molecules with potential applications in different industries.

Upstream product

• 105788-20-3 3-(4-methoxy-phenyl)-2,2-dimethyl-propionic acid amide 
• 824-94-2 p-methoxybenzyl chloride 
• 79-31-2 isobutyric Acid 
• 1035155-37-3 ethyl 2,2-dimethyl-3-(4-methoxyphenyl)propanoate 
• 14248-23-8 methyl 3-(4-methoxyphenyl)-2,2-dimethylpropanoate 
• 622-95-7 4-chlorobenzyl bromide 

Downstream Products

• 56490-94-9 1-(2-amino-2-methylpropyl)-4-methoxybenzene 
• 100390-34-9 2-(4-methoxy-phenyl)-1,1-dimethyl-ethyl isocyanate 
• 81279-26-7 1--1,1-dimethyl-2-(4-methoxyphenyl)ethane 
• 1308788-40-0 3-(4-methoxyphenyl)-2,2-dimethyl-N-(pyridin-2-ylmethyl)propanamide 
• 1308788-87-5 3-(4-methoxybenzyl)-3-methyl-1-(pyridin-2-ylmethyl)pyrrolidine-2,5-dione 
• 1384980-69-1 N-[3-acetoxy-2-(4-methoxybenzyl)-2-methylpropanoyl]-S-methyl-S-2-pyridylsulfoximine 
• 1384980-50-0 N-[2,2-dimethyl-3-(4-methoxyphenyl)propanoyl]-S-methyl-S-2-pyridylsulfoximine 
• 1613145-78-0 3-(4-methoxyphenyl)-2,2-dimethyl-N-(quinolin-8-yl)propanamide 
• 56490-93-8 1,1-dimethyl-2-(4-methoxyphenyl)ethylamine hydrochloride 

Relevant articles and documents

Diradicals Photogeneration from Chloroaryl-Substituted Carboxylic Acids

With the aim of generating new, thermally inaccessible diradicals, potentially able to induce a double-strand DNA cleavage, the photochemistry of a set of chloroaryl-substituted carboxylic acids in polar media was investigated. The photoheterolytic cleavage of the Ar?Cl bond occurred in each case to form the corresponding triplet phenyl cations. Under basic conditions, the photorelease of the chloride anion was accompanied by an intramolecular electron-transfer from the carboxylate group to the aromatic radical cationic site to give a diradical species. This latter intermediate could then undergo CO2 loss in a structure-dependent fashion, according to the stability of the resulting diradical, or abstract a hydrogen atom from the medium. In aqueous environment at physiological pH (pH=7.3), both a phenyl cation and a diradical chemistry was observed. The mechanistic scenario and the role of the various intermediates (aryl cations and diradicals) involved in the process was supported by computational analysis.

Highly regioselective carbonylation of unactivated C(sp3)-H bonds by ruthenium carbonyl

The regioselective carbonylation of unactivated C(sp3)-H bonds of aliphatic amides was achieved using Ru3(CO)12 as a catalyst. The presence of a 2-pyridinylmethylamine moiety in the amide is crucial for a successful reaction. The reaction shows a preference for C-H bonds of methyl groups as opposed to methylene C-H bonds and tolerates a variety of functional groups. The stoichiometric reaction of an amide with Ru 3(CO)12 gave a dinuclear ruthenium complex in which the 2-pyridinylmethylamino moiety was coordinated to the ruthenium center in an N,N manner.

CALCILYTIC COMPOUNDS

Novel calcilytic compounds, pharmaceutical compositions, methods of synthesis and methods of using them are provided.