29228-83-9Relevant articles and documents
A practical synthesis and spectroscopic study of new potentially biologically active S-lithocholic acid-substituted derivatives of 2-thiouracil
Pospieszny, Tomasz,Ma?ecka, Izabela,Paryzek, Zdzis?aw
, p. 4166 - 4169 (2010)
Five new S-3α-acetoxy-5β-lithocholic acid methyl ester-substituted derivatives of 2-thiouracil and 6-methyl-2-thiouracil have been prepared. 5-Morpholino-methyl-2-thiouracil, 5-piperidinomethyl-2- thiouracil, and 5-(4-methylpiperidino)methyl-2-thiouracil have been obtained via the Mannich reaction between 6-methyl-2-thiouracil, paraformaldehyde, and the cyclic secondary amines morpholine, piperidine, or 4-methylpiperidine in ethanol. The structures of the compounds were confirmed by spectral ( 1H NMR, 13C NMR, and FT-IR) analyses and mass spectrometry. Estimation of the pharmacotherapeutic potential has been accomplished for the synthesized compounds on the basis of Prediction of Activity Spectra for Substances (PASS).