29247-79-8

Basic information

• Product Name: N-p-toluenesulfonyl-4-chloro-anthranilic acid methyl ester
• Synonyms: N-p-toluenesulfonyl-4-chloro-anthranilic acid methyl ester
• CAS NO: 29247-79-8
• Molecular Weight: 339.799
• Mol File: 29247-79-8.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: N-p-toluenesulfonyl-4-chloro-anthranilic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: N-p-toluenesulfonyl-4-chloro-anthranilic acid methyl ester(29247-79-8)
• EPA Substance Registry System: N-p-toluenesulfonyl-4-chloro-anthranilic acid methyl ester(29247-79-8)

Safety Data

• Hazardous Substances Data: 29247-79-8(Hazardous Substances Data)

Upstream product

• 42087-80-9 methyl 4-chloro-2-nitrobenzoate 
• 6280-88-2 4-chloro-2-nitro-benzoic acid 
• 89-77-0 2-Amino-4-chlorobenzoic acid 
• 5900-58-3 2-amino-4-chloro-benzoic acid methyl ester 
• 98-59-9 p-toluenesulfonyl chloride 

Downstream Products

• 38314-48-6 8-chloro-5-oxo-1-(toluene-4-sulfonyl)-2,3,4,5-tetrahydro-1H-benzo[b]azepine-4-carboxylic acid methyl ester 
• 137984-96-4 1-(4-aminobenzoyl)-8-chloro-5-oxo-2,3,4,5-tetrahydro-1H-1-benzazepine 
• 137984-93-1 8-chloro-1-(4-nitrobenzoyl)-5-oxo-2,3,4,5-tetrahydro-1H-1-benzazepine 
• 137977-41-4 8-chloro-1-[4-[(2-methylbenzoyl)amino]benzoyl]-5-oxo-2,3,4,5-tetrahydro-1H-1-benzazepine 
• 154890-41-2 8-chloro-5-(N-methylamino)-1-[4-[(2-methylbenzoyl)amino]benzoyl]-2,3,4,5-tetrahydro-1H-1-benzazepine 
• 105896-03-5 4-amino-9-chloro-7-tosyl-6,7-dihydro-5H-pyrimido<5,4-d><1>benzazepine 
• 105896-02-4 8-chloro-5-hydroxy-1-tosyl-2,3-dihydro-1H-1-benzazepine-4-carbonitrile 
• 271248-58-9 8-chloro-1-(2-methylbenzoyl)-1,2,3,4-tetrahydro-1-benzazepin-5-one 
• 116815-03-3 8-chloro-1,2,3,4-tetrahydro-5H-benzo[b]azepin-5-one 
• 143771-90-8 8-Chloro-5-oxo-1-(toluene-4-sulfonyl)-2,3,4,5-tetrahydro-1H-benzo[b]azepine-4-carboxylic acid ethyl ester 
• 38314-49-7 8-chloro-5-oxo-2,3,4,5-tetrahydro-1-p-toluenesulfonyl-1H-1-benzazepine 
• 402822-78-0 N-allyl-N-p-toluenesulfonyl-5-chloro-2-ethenylaniline 
• 675578-49-1 N-allyl-N-p-toluenesulfonyl-5-chloro-2-formylaniline 
• 135484-70-7 N-(5-chloro-2-formylphenyl)-4-methylbenzenesulfonamide 

Relevant articles and documents

Iodine(III) Reagent-Mediated Intramolecular Amination of 2-Alkenylanilines to Prepare Indoles

A variety of 3-substituted and 2,3-disubstituted indoles were synthesized efficiently in good yields through the intramolecular amination of 2-alkenylanilines promoted by readily available iodine(III) reagents in a short reaction time. Mechanistic studies showed that the reaction pathway went through a nitrenium ion and that 3-acetoxy indoline was the key intermediate in the indole formation. The indole product was easily prepared on a gram scale and amination also proceeded smoothly using catalytic 3,5-dimethylphenyl iodine in the presence of mCPBA. Furthermore, the indolo[3,2-a]carbazole scaffold was prepared in good yield in six steps from commercial ortho-iodoaniline. (Figure presented.).

Synthesis of substituted 1,2-dihydroquinolines and quinolines using ene-ene metathesis and ene-enol ether metathesis

We describe a novel and convenient method for quinoline synthesis using ring-closing olefin metathesis (RCM), ene-ene metathesis, and ene-enol ether metathesis. We also report the first example of enol silyl ether-ene metathesis to produce cyclic enol silyl ether. Using this method, versatile substituted quinoline derivatives were readily prepared in excellent yield from anthranilic acid derivatives.

7-Chloro-5-hydroxy-1-[2-methyl-4-(2-methylbenzoylamino)benzoyl]-2,3,4,5- tetrahydro-1H-1-benzazepine (OPC-41061): A potent, orally active nonpeptide arginine vasopressin V2 receptor antagonist

We previously reported a series of benzazepine derivatives as orally active nonpeptide arginine vasopressin (AVP) V2 receptor antagonists. After the lead structure OPC-31260 was structurally evaluated and optimized, the introduction of the 7-Cl moiety on the benzazepine and 2-CH3 on the aminobenzoyl moiety enhanced its oral activity. The new AVP-V2 selective antagonist OPC-41061 was determined to be a potent and orally active agent. Copyright (C) 1999 Elsevier Science Ltd.