29277-46-1

Basic information

• Product Name: N-(2-Methoxyphenyl) Ethanethioamide
• Synonyms: N-(2-Methoxyphenyl) Ethanethioamide;Ethanethioamide, N-(2-methoxyphenyl)-
• CAS NO: 29277-46-1
• Molecular Formula: C₉H₁₁NOS
• Molecular Weight: 181.25474
• Mol File: 29277-46-1.mol
• Article Data: 9

Chemical Properties

• Appearance: /
• CAS DataBase Reference: N-(2-Methoxyphenyl) Ethanethioamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2-Methoxyphenyl) Ethanethioamide(29277-46-1)
• EPA Substance Registry System: N-(2-Methoxyphenyl) Ethanethioamide(29277-46-1)

Safety Data

• Hazardous Substances Data: 29277-46-1(Hazardous Substances Data)

Upstream product

• 93-26-5 2-methoxyacetanilide 
• 90-04-0 2-methoxy-phenylamine 
• 54582-21-7 2-methoxyacetophenone oxime 

Downstream Products

• 5304-19-8 4-methoxy-2-methylbenzo[d]thiazole 
• 94977-59-0 2-methyl-4-hydroxybenzothiazole 
• 199849-85-9 2-amino-N-[2,4-dichloro-3-(2-methyl-benzothiazol-4-yloxymethyl)-phenyl]-N-methyl-acetamide 
• 26749-57-5 1-(4-methoxy-2-methyl-benzothiazol-7-yl)-ethanone 
• 1312609-99-6 C₁₈H₁₅NO₂S 
• 1312611-67-8 C₁₈H₁₃Br₂NO₂S 
• 1312610-00-6 C₄₂H₅₁N₅O₁₂S 
• 1312608-57-3 C₄₂H₅₁N₉O₆S 

Relevant articles and documents

ALPHA, BETA-UNSATURATED AMIDE COMPOUND

An object of the present invention is to provide an α,β-unsaturated amide compound or a pharmaceutically acceptable salt or the like thereof having anticancer activity and the like. The α,β-unsaturated amide compound represented by the following formula (I) or a pharmaceutically acceptable salt or the like thereof has anticancer activity and the like: [wherein, "A" represents optionally substituted heterocyclic diyl, R1 represents hydrogen atom or optionally substituted lower alkyl, R2 represents optionally substituted aryl, optionally substituted cycloalkyl, optionally substituted aliphatic heterocyclic group or optionally substituted aromatic heterocyclic group, X represents -O-, -S-, -SO2-, -NRX1- (wherein, RX1 represents hydrogen atom or lower alkyl), -CHRX2- (wherein, RX2 represents hydrogen atom or hydroxy), -CH=CH-, -CO- or -NH-CO-, and n1 and n2 are the same or different, and each represents 0 or 1].

Facile and odorless one-pot process for the synthesis of N-substituted thioamides via TsCl-mediated Beckmann rearrangement of ketoximes

A facile and odorless one-pot thionation process for the synthesis of N-substituted thioamides using chemically stable and inexpensive thiourea reagent via the Beckmann rearrangement of ketoximes, has been described. Georg Thieme Verlag Stuttgart · New York.

Searching for new cures for tuberculosis: Design, synthesis, and biological evaluation of 2-methylbenzothiazoles

The actual development and clinical use of new therapeutics for tuberculosis (TB) have remained stagnant for years because of the complexity of the disease process, the treatment of which at present requires the administration of drug combinations over a 6month period. There is thus an urgent need for the discovery and development of novel, more active, and less toxic anti-TB agents. In this study, we report on the chemistry and biology of a series of potent 5-(2-methylbenzothiazol-5-yloxymethyl) isoxazole-3-carboxamide derivatives, which proved to be active against replicating Mycobacterium tuberculosis (Mtb) H37Rv. The most potent compounds 7j and 7s were found to inhibit Mtb growth at micromolar concentrations, with MICvalues of 1.4 and 1.9 μM, respectively. Impressively, all active compounds were nontoxic toward Vero cells (IC50 > 128 μM). Moreover, the best of these compounds were also tested against protozoan parasites, and some of these compounds were found to show activity, especially against Plasmodium falciparum. These studies thus suggest that certain 2-methylbenzothiazole based compounds may serve as promising lead scaffolds for further elaboration as anti-TB drugs and as possible antimalaria drugs. 2009 American Chemical Society.