29277-73-4 Usage
Description
2-[4-[(2RS)-2-HYDROXY-3[(1-METHYLETHYL)AMINO]PROPOXY]PHENYL]ACETONITRILE is a chemical compound with a complex structure, characterized by its unique arrangement of hydroxy, amino, and propoxy groups attached to a phenyl ring. 2-[4-[(2RS)-2-HYDROXY-3[(1-METHYLETHYL)AMINO]PROPOXY]PHENYL]ACETONITRILE is known for its presence as an impurity in Atenolol, a cardioselective β-adrenergic blocker used in the treatment of various cardiovascular conditions.
Uses
Used in Pharmaceutical Industry:
2-[4-[(2RS)-2-HYDROXY-3[(1-METHYLETHYL)AMINO]PROPOXY]PHENYL]ACETONITRILE is used as an impurity in the production of Atenolol (A790075), a cardioselective β-adrenergic blocker. Its presence in the manufacturing process of Atenolol is significant, as it can impact the drug's efficacy and safety profile. 2-[4-[(2RS)-2-HYDROXY-3[(1-METHYLETHYL)AMINO]PROPOXY]PHENYL]ACETONITRILE is classified as Atenolol EP Impurity H, and its control and monitoring are essential to ensure the quality and consistency of the final pharmaceutical product.
Check Digit Verification of cas no
The CAS Registry Mumber 29277-73-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,9,2,7 and 7 respectively; the second part has 2 digits, 7 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 29277-73:
(7*2)+(6*9)+(5*2)+(4*7)+(3*7)+(2*7)+(1*3)=144
144 % 10 = 4
So 29277-73-4 is a valid CAS Registry Number.
29277-73-4Relevant articles and documents
Mechanistic Insight Facilitates Discovery of a Mild and Efficient Copper-Catalyzed Dehydration of Primary Amides to Nitriles Using Hydrosilanes
Liu, Richard Y.,Bae, Minwoo,Buchwald, Stephen L.
supporting information, p. 1627 - 1631 (2018/02/17)
Metal-catalyzed silylative dehydration of primary amides is an economical approach to the synthesis of nitriles. We report a copper-hydride(CuH)-catalyzed process that avoids a typically challenging 1,2-siloxane elimination step, thereby dramatically increasing the rate of the overall transformation relative to alternative metal-catalyzed systems. This new reaction proceeds at ambient temperature, tolerates a variety of metal-, acid-, or base-sensitive functional groups, and can be performed using a simple ligand, inexpensive siloxanes, and low catalyst loading.
Attempts to synthesize new β1 receptor blockers
Eckardt,Carstens,Fiedler
, p. 633 - 637 (2007/10/06)
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