293-30-1

Basic information

• Product Name: Tetraoxane
• Synonyms: 1,3,5,7-Tetraoxacyclooctane;Tetraoxane
• CAS NO: 293-30-1
• Molecular Formula: C₄H₈O₄
• Molecular Weight: 120.1039
• Mol File: 293-30-1.mol
• Article Data: 2

Chemical Properties

• Melting Point: 112 °C
• Boiling Point: 141.8°Cat760mmHg
• Flash Point: 76.1°C
• Appearance: /
• Density: 1.131g/cm³
• Vapor Pressure: 7.19mmHg at 25°C
• Refractive Index: 1.385
• CAS DataBase Reference: Tetraoxane(CAS DataBase Reference)
• NIST Chemistry Reference: Tetraoxane(293-30-1)
• EPA Substance Registry System: Tetraoxane(293-30-1)

Safety Data

• Hazardous Substances Data: 293-30-1(Hazardous Substances Data)

Usage

General Description

Tetraoxane is a chemical compound with the molecular formula C8H16O4. It is a cyclic peroxide that is used as a powerful antimalarial agent and it is also an important synthetic intermediate in organic chemistry. Tetraoxane exhibits high activity against resistant strains of malaria parasites and has been used as a component in combination therapy for treating malaria. It is known for its rapid action and ability to clear the parasites from the bloodstream, making it an effective and vital tool in the fight against malaria. However, due to its peroxide structure, tetraoxane is highly unstable and reactive, requiring careful handling and storage to prevent decomposition and inadvertent detonation.

InChI:InChI=1/C4H8O4/c1-5-2-7-4-8-3-6-1/h1-4H2

Upstream product

• 50-00-0 formaldehyd 
• 108-24-7 acetic anhydride 
• 79-34-5 1,1,2,2-tetrachloroethane 

Downstream Products

• 79-10-7 acrylic acid 

Relevant articles and documents

Computational and NMR Studies on the Complexation of Lithium Ion to 8-Crown-4

Lithium ion selective crown ethers have been the subject of much research for a multitude of applications. Current research is aimed at structurally rigidifying crown ethers, as restructuring of the crown ether ring upon ion binding is energetically unfavorable. In this work, the lithium ion binding ability of the relatively rigid 8-crown-4 was investigated both computationally by density functional theory calculations and experimentally by 1H and 7Li NMR spectroscopy. Although both computational and experimental results showed 8-crown-4 to bind lithium ion, this binding was found to be weak compared to larger crown ethers. The computational analysis revealed that the complexation is driven by enthalpy rather than entropy, illustrating that rigidity is only of nominal importance. To elucidate the origin of the favorable interaction of lithium ion with crown ethers, activation strain analyses and energy decomposition analyses were performed pointing to the favorable interaction being mainly electrostatic in nature. 8-crown-4 presents the smallest crown ether reported to date capable of binding lithium ion, possessing two distinct conformations from which it is able to do so.