29310-39-2Relevant articles and documents
Synthesis of 3D-Rich Heterocycles: Hexahydropyrazolo[1,5-A]pyridin-2(1H)-ones and Octahydro-2H-2a,2a1-diazacyclopenta[cd]inden-2-ones
Pu?avec Kirar, Eva,Drev, Miha,Mirnik, Jona,Gro?elj, Uro?,Golobi?, Amalija,Dahmann, Georg,Po?gan, Franc,?tefane, Bogdan,Svete, Jurij
, p. 8920 - 8933 (2016/10/14)
Two cyclic azomethine imines, 7-methyl- and 7-phenyl-2-oxo-Δ7-hexahydropyrazolo[1,5-A]pyridin-8-ium-1-ide, were prepared in seven steps from the respective commercially available δ-keto acids. The addition of Grignard reagents followed by N-Alkylation at position 1 afforded the 1,7,7-trisubstituted hexahydropyrazolo[1,5-A]pyridin-2(1H)-ones, whereas 1,3-dipolar cycloadditions of these dipoles to typical acetylenic and olefinic dipolarophiles gave 4a-substituted 2a,2a1-diazacyclopenta[cd]indene derivatives as the first representatives of a novel heterocyclic system. Regio- and stereoselectivity as well as the mechanism of these [3 + 2]-cycloadditions were evaluated using computational and experimental methods. The data obtained were in agreement with the polar concerted cycloaddition mechanism via the energetically favorable syn/endo-transition states.
Two convenient syntheses of brevicomin
Dandge, Chitra N,Naik, D G,Kapadi, A H
, p. 617 - 619 (2007/10/02)
Synthesis of brevicomin, 7-ethyl-7-methyl-6,8-dioxabicyclooctane (1), the aggregation pheromone of Western pine beetle, Dendroctonus brevicomis, by simple routes is described.
