293313-46-9Relevant articles and documents
(Alkylthio)alkynes as addends in the Co(0) catalyzed intramolecular pauson-khand reaction. Substituent driven enhancements of annulation efficiency and stereoselectivity
Pagenkopf, Brian L.,Belanger, David B.,O'Mahony, Donogh J. R.,Livinghouse, Tom
, p. 1009 - 1019 (2000)
Compared to terminal alkynes, (methylthio)alkynes are generally superior substrates for the thermally promoted, Co2(CO)8 catalyzed Pauson-Khand reaction of enynes and allenynes, providing enones in higher yields and with enhanced diastereoselectivity. Improvements in yield dependent upon the use of 2,2,2-trifluoroethanol as co-solvent and an apparent preference for endo selectivity with (ethoxy)alkynes are also disclosed.