29338-47-4

Basic information

• Product Name: Benzene, 1-nitro-3-(phenylethynyl)-
• CAS NO: 29338-47-4
• Molecular Formula: C14H9NO2
• Molecular Weight: 223.231
• Mol File: 29338-47-4.mol
• Article Data: 111

Chemical Properties

• CAS DataBase Reference: Benzene, 1-nitro-3-(phenylethynyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, 1-nitro-3-(phenylethynyl)-(29338-47-4)
• EPA Substance Registry System: Benzene, 1-nitro-3-(phenylethynyl)-(29338-47-4)

Safety Data

• Hazardous Substances Data: 29338-47-4(Hazardous Substances Data)

Upstream product

• 13146-23-1 copper(I) phenylacetylenide 
• 645-00-1 m-iodonitrobenzene 
• 536-74-3 phenylacetylene 
• 585-79-5 m-nitrobromobenzene 
• 121-73-3 3-Nitrochlorobenzene 
• 1719-19-3 2-Methyl-4-phenyl-3-butyn-2-ol 
• 201230-82-2 carbon monoxide 
• 25411-73-8 diethyl diazomethylphosphonate 
• 2243-80-3 3-nitrobenzophenone 
• 17508-17-7 O-(2,4-dinitrophenyl)hydroxylamine 
• 183322-33-0 1-nitro-3-[2-(trimethylsilyl)ethynyl]benzene 
• 591-50-4 iodobenzene 
• 99-61-6 3-nitro-benzaldehyde 
• 90965-06-3 dimethyl 1-(1-diazo-2-oxopropyl)phosphonate 

Downstream Products

• 51624-44-3 1-(3-aminophenyl)-2-phenylacetylene 
• 56856-43-0 1-(3-nitrophenyl)-2-phenylethane-1,2-dione 
• 20802-08-8 2-(3-nitrophenyl)-1-phenylethan-1-one 
• 1049647-31-5 C₁₆H₁₄N₄O₃ 
• 1443019-42-8 7-(3-nitro-phenyl)-8-phenyl-bicyclo[4.2.1]nona-2,4,7-triene 
• 1309855-33-1 1,3-bis(3-nitrophenyl)-2,3-diphenylcyclopenta[b]chromen-9(3H)-one 
• 1309855-34-2 2,3-bis(3-nitrophenyl)-1,3-diphenylcyclopenta[b]chromen-9(3H)-one 

Relevant articles and documents

Palladium catalyzed cross coupling of diaryliodonium salts with copper acetylide

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Decorated palladium nanoparticles on mesoporous organosilicate as an efficient catalyst for Sonogashira coupling reaction

Abstract: Reforming mesoporous silica was provided by the reaction of SBA‐15 with (3-aminopropyl)triethoxysilane, the product of which was treated with furfural to give SBA-propyl-imine-furan. In the next step, palladium chloride was attached to the funct

A Waste-Minimized Approach to Cassar-Heck Reaction Based on POLITAG-Pd0 Heterogeneous Catalyst and Recoverable Acetonitrile Azeotrope

Three different Pd0-based heterogeneous catalysts were developed and tested in the Cassar–Heck reaction (i. e., copper-free Sonogashira reaction) aiming at the definition of a waste minimized protocol. The cross-linked polymeric supports used in this investigation were designed to be adequate for different reaction media and were decorated with different pincer-type ionic ligands having the role of stabilizing the formation and dimension of palladium nanoparticles. Among the ionic tags tested, bis-imidazolium showed the best performances in terms of efficiency and durability of the metal catalytic system. Eventually, aqueous acetonitrile azeotrope was selected as the reaction medium as it allowed the best catalytic efficiency combined with easy recovery and reuse. Finally, the synergy between the selected catalyst and reaction medium allowed to obtain highly satisfactory isolated yields of a variety of substrates while using a low amount of metal catalyst. The high performance of the designed POLymeric Ionic TAG (POLITAG)-Pd0, along with its good selectivity achieved in a copper-free process, also led to a simplified purification procedure allowing the minimization of the waste generated as also proven by the very low E-factor values (1.4–5) associated.

Ligand-Promoted Alkynylation of Aryl Ketones: A Practical Tool for Structural Diversity in Drugs and Natural Products

Conversion of the numerous aryl ketones into aryl electrophiles via Ar-C(O) cleavage remains a challenging yet highly desirable transformation in Sonogashira-type coupling. Herein, we report a palladium-catalyzed ligand-promoted alkynylation of unstrained aryl ketones. The protocol allows the alkynylation to be carried out in a one-pot procedure with broad functional-group tolerance and substrate scope. The potential applications of this protocol in drug discovery and chemical biology are further demonstrated by late-stage diversification of a number of pharmaceuticals and natural products. More importantly, two different biologically important fragments derived from a pharmaceutical and natural product could be connected by the consecutive alkynylation of ketones. Distinct from aryl halides in conventional Sonogashira reactions, the protocol provides a practical tool for the 1,2-bifunctionalization of aryl ketone by merging ketone-directed ortho-C-H activation with ligand-promoted ipso-Ar-C(O) alkynylation.