2937-81-7Relevant articles and documents
Synthesis and properties of diaminothiadiazoles
Melenchuk,Danilova,Stryapan,Islyaikin
, p. 480 - 484 (2008)
Refined synthetic procedure for preparation of 3,5-diamino-1,2,4- thiadiazole and 2,5-diamino-1,3,4-thiadiazole based on the reaction of dithiourea or amidinothiourea with hydrogen peroxide is developed. The optimal reagents ratio was found, and monitoring methods were developed. It resulted in the increase of the target product yield and in a shorter reaction time. On the basis of 2,5-diamino-1,3,4-thiadiazole the alkylsubstituted 1,3,4- diaminothiadiazolidines were synthesized. The compounds prepared were characterized by the elemental analysis data, the IR, 1H NMR, and electronic spectra, and also by mass spectrometry.
Synthesis and molecular docking of hybrids ionic azole Schiff bases as novel CDK1 inhibitors and anti-breast cancer agents: In vitro and in vivo study
Abdelghany, Yasmin M.,Abdelhamid, Moustafa S.,Elshaarawy, Reda F. M.,Serag, Waleed M.,Zahran, Faten
, (2021)
Three new hybrid ionic vanillyl-azole-Schiff bases (IVASBs) have synthesized and their antitumor performances were assessed in vitro against MCF-7 cells and in vivo against Ehrlich solid tumor (EST). The high binding energy score of IVASB3?CDK1 (?3.43 kca
Composition of matter having bioactive properties
-
, (2008/06/13)
Particles of coordinated complex comprising a basic, hydrous polymer and a capacitance adding compound, as well as methods for their production, are described. These complexes exhibit a high degree of bioactivity making them suitable for a broad range of applications through their incorporation into conventional vehicles benefiting from antimicrobial and similar properties.