293738-21-3

Basic information

• Product Name: 2-(4-TERT-BUTYL-PHENYL)-BENZOOXAZOL-5-YLAMINE
• Synonyms: 2-(4-TERT-BUTYL-PHENYL)-BENZOOXAZOL-5-YLAMINE;2-(4-TERT-BUTYLPHENYL)BENZOXAZOL-5-YLAMINE;2-[4-(TERT-BUTYL)PHENYL]-1,3-BENZOXAZOL-5-AMINE;LABOTEST-BB LT00143628;ASISCHEM T31064;ART-CHEM-BB B025119;[2-(4-tert-butylphenyl)-1,3-benzoxazol-5-yl]amine;BAS 00272852
• CAS NO: 293738-21-3
• Molecular Formula: C₁₇H₁₈N₂O
• Molecular Weight: 266.34
• Mol File: 293738-21-3.mol
• Article Data: 9

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-(4-TERT-BUTYL-PHENYL)-BENZOOXAZOL-5-YLAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-TERT-BUTYL-PHENYL)-BENZOOXAZOL-5-YLAMINE(293738-21-3)
• EPA Substance Registry System: 2-(4-TERT-BUTYL-PHENYL)-BENZOOXAZOL-5-YLAMINE(293738-21-3)

Safety Data

• Hazardous Substances Data: 293738-21-3(Hazardous Substances Data)

Usage

Class

Benzooxazoles (heterocyclic aromatic compounds)

Structure

Substituted benzene ring with a tert-butyl group and a benzooxazole ring with an amine group

Application

Fluorescent whitening agent in plastics, fibers, and coatings

Function

Absorbs UV light and emits blue light to enhance brightness and whiteness of materials

Additional uses

Fluorescent tracer in biological research and light stabilizer in polymers

Upstream product

• 137-09-7 2,4-diaminophenol dihydrochloride 
• 98-73-7 4-(1,1-dimethylethyl)benzoic acid 

Downstream Products

• 346646-36-4 C₂₆H₂₂N₂O₃ 

Relevant articles and documents

Design, synthesis, molecular docking, density functional theory and antimicrobial studies of some novel benzoxazole derivatives as structural bioisosteres of nucleotides

A series of some novel 2-(p-tert-butylphenyl)-5-(3-substituted-propionamido)benzoxazole derivatives have been designed, synthesized, evaluated for antimicrobial activity and have performed molecular docking studies against penicillin-binding protein 4 (PBP4) and active and allosteric site of PBP2a; were calculated some theoretical quantum parameters and absorption, distribution, metabolism and excretion (ADME) descriptors. B9 acted at minimum inhibitory concentration (MIC) = 8 μg/mL against S. aureus, E. faecalis and their drug-resistant isolates and also formed with GLU145 (1.74 ?) and ILE144 (1.89 ?) two hydrogen bonds at allosteric site of PBP2a with Glide emodel score: ?42.168. ΔE of compound B9 had moderate value of all compounds with 0.14742. (Figure presented.) Communicated by Ramaswamy H. Sarma.

Synthesis, vibrational spectroscopic investigations, molecular docking, antibacterial studies and molecular dynamics study of 5-[(4-nitrophenyl)acetamido]-2-(4-tert-butylphenyl)benzoxazole

Antimicrobial active 5-[(4-nitrophenyl)acetamido]-2-(4-tert-butylphenyl)benzoxazole (NATPB) was synthesized and observed IR, Raman bands are compared with the theoretically predicted wave numbers. In the IR spectrum the NH stretching wave number splits in

Anticancer supplement agent including benzo[D]oxazol derivative as effective ingredient

Disclosed is an anticancer supplement agent including a benzo[d]oxazole derivative as an effective ingredient. The benzo[d]oxazole derivative, which is a nuclear factor E2-related factor 2 (Nrf2) inhibitor, is capable of inhibiting activity of Nrf2 that induces an antioxidant enzyme to remove reactive oxygen species (ROS) that kills a cancer cell, thereby increasing production of ROS. Therefore, the benzo[d]oxazole derivative can be used as an anticancer supplement agent that shows therapeutic effects in anticancer agent therapy or radiation therapy, and in this regard, the benzo[d]oxazole derivative can overcome tolerance of the cancer cell to anticancer agent therapy or radiation therapy and enhance apoptotic effects on the cancer cell.