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294174-66-6

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  • 5-[Bis(2-chloroethyl)amino]-2-benzofurancarboxylic acid ethyl ester

    Cas No: 294174-66-6

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294174-66-6 Usage

General Description

5-[Bis(2-chloroethyl)amino]-2-benzofurancarboxylic acid ethyl ester is a chemical compound that belongs to the class of nitrogen mustard alkylating agents, which are widely used in chemotherapy to treat various types of cancer. 5-[Bis(2-chloroethyl)amino]-2-benzofurancarboxylic acid ethyl ester is an ethyl ester derivative of the carboxylic acid 5-[Bis(2-chloroethyl)amino]-2-benzofurancarboxylic acid, and it is known for its ability to alkylate DNA, ultimately leading to the inhibition of cancer cell growth and division. However, it also poses serious health risks, such as genotoxicity and carcinogenicity, and it must be handled with utmost care and caution in laboratory and medical settings. Overall, this chemical compound is an important tool in cancer treatment, but its potential hazards should not be overlooked.

Check Digit Verification of cas no

The CAS Registry Mumber 294174-66-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,9,4,1,7 and 4 respectively; the second part has 2 digits, 6 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 294174-66:
(8*2)+(7*9)+(6*4)+(5*1)+(4*7)+(3*4)+(2*6)+(1*6)=166
166 % 10 = 6
So 294174-66-6 is a valid CAS Registry Number.

294174-66-6SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 5-[Bis-(2-chloro-ethyl)-amino]-benzofuran-2-carboxylic acid ethyl ester

1.2 Other means of identification

Product number -
Other names 5-[Bis(2-chloroethyl)amino]-2-benzofurancarboxylic acid ethyl ester

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:294174-66-6 SDS

294174-66-6Downstream Products

294174-66-6Relevant articles and documents

Synthesis and antitumor activity of new benzoheterocyclic derivatives of distamycin A

Baraldi, Pier Giovanni,Romagnoli, Romeo,Beria, Italo,Cozzi, Paolo,Geroni, Cristina,Mongelli, Nicola,Bianchi, Nicoletta,Mischiati, Carlo,Gambari, Roberto

, p. 2675 - 2684 (2007/10/03)

The design, synthesis, and in vivo and in vitro antileukemic activity of a novel series of compounds (13-22 and 34), in which different benzoheterocyclic rings, bearing a nitrogen mustard or a benzoyl nitrogen mustard or an α-bromoacryloyl group as alkylating moieties, are tethered to a distamycin frame, are reported, and structure-activity relationships are discussed. The new derivatives were prepared by coupling nitrogen mustard- substituted, benzoyl nitrogen mustard-substituted, or α- bromoacryloyl-substituted benzoheterocyclic carboxylic acids 23- 32 with desformyldistamycin (33) or in one case with its two- pyrrole analogue 35. With very few exceptions, the activities of compounds bearing the same alkylating moiety are slightly affected by the kind of the heteroatom present on the benzoheterocyclic ring. All novel compounds, with one exception, showed in vitro activity against L1210 murine leukemia cell line comparable to or better than that of tallimustine. The compounds in which the nitrogen mustard and the α-bromoacryloyl moieties are directly linked to benzoheterocyclic ring showed potent cytotoxic activities (IC50 ranging from 2 to 14 nM), while benzoyl nitrogen mustard derivatives of benzoheterocycles showed reduced cytotoxic activities, and one compound (16) of this cluster was the sole derivative devoid of significant activity. Compound 18, a 5-nitrogen mustard N-methylindole derivative of distamycin, showed the best antileukemic activity in vivo, with a very long survival time (%T/C = 457), significantly increased in comparison to tallimustine (%T/C = 133), and was selected for further extensive evaluation. Arrested polymerase chain reaction and direct DNA fragmentation assays were performed for compound 18 and the structurally related compounds 13-17 and 19. The results obtained have shown that both alkylating groups and oligopeptide frames play a crucial role in the sequence selectivity of these compounds.

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