294177-74-5Relevant articles and documents
α-Ketoamides as Broad-Spectrum Inhibitors of Coronavirus and Enterovirus Replication: Structure-Based Design, Synthesis, and Activity Assessment
Zhang, Linlin,Lin, Daizong,Kusov, Yuri,Nian, Yong,Ma, Qingjun,Wang, Jiang,Von Brunn, Albrecht,Leyssen, Pieter,Lanko, Kristina,Neyts, Johan,De Wilde, Adriaan,Snijder, Eric J.,Liu, Hong,Hilgenfeld, Rolf
, p. 4562 - 4578 (2020/03/05)
The main protease of coronaviruses and the 3C protease of enteroviruses share a similar active-site architecture and a unique requirement for glutamine in the P1 position of the substrate. Because of their unique specificity and essential role in viral po
Studies of the new reactivity of chiral acrylamides and unprotected pyrroles: Diastereoselective and carbonyl compatible 1,4-addition
Gratais, Alexandre,Pannecoucke, Xavier,Bouzbouz, Samir
supporting information, p. 1555 - 1560 (2014/07/08)
A diversity of new functionalized cyclic and acyclic chiral pyrroloamides compounds were synthesized in good yields and diastereoselectivities in the case of cyclic pyrroloamides. This simple and robust process involves the creation of a C-C bond between unprotected pyrroles and cyclic or hindered chiral acrylamides. Georg Thieme Verlag Stuttgart New York.