29418-67-5

Basic information

• Product Name: 2-BROMOBENZHYDRAZIDE
• Synonyms: Benzoic acid, 2-bromo-, hydrazide;ASISCHEM D51117;LABOTEST-BB LT00454068;AKOS B020273;2-BROMOBENZHYDRAZIDE;2-BROMOBENZOIC ACID HYDRAZIDE;2-BROMOBENZOIC HYDRAZIDE;2-bromobenzohydrazide
• CAS NO: 29418-67-5
• Molecular Formula: C₇H₇BrN₂O
• Molecular Weight: 215.05
• EINECS: 249-614-2
• Product Categories: Aromatic Hydrazides, Hydrazines, Hydrazones and Oximes;Benzoic acid;Bromine Compounds
• Mol File: 29418-67-5.mol
• Article Data: 53

Chemical Properties

• Melting Point: 152-154°C
• Boiling Point: 367.2 °C at 760 mmHg
• Flash Point: 175.9 °C
• Appearance: /
• Density: 1.615 g/cm³
• Vapor Pressure: 4.87E-06mmHg at 25°C
• Refractive Index: 1.615
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• Solubility: soluble in Methanol
• PKA: 11.92±0.10(Predicted)
• BRN: 1941021
• CAS DataBase Reference: 2-BROMOBENZHYDRAZIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-BROMOBENZHYDRAZIDE(29418-67-5)
• EPA Substance Registry System: 2-BROMOBENZHYDRAZIDE(29418-67-5)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-36
• HazardClass: IRRITANT
• Hazardous Substances Data: 29418-67-5(Hazardous Substances Data)

Usage

General Description

2-Bromobenzhydrazide is a chemical compound with the molecular formula C7H7BrN2O. It is primarily used as a building block in the synthesis of pharmaceuticals and agrochemicals. 2-Bromobenzhydrazide has been found to exhibit antimicrobial properties, and has potential applications in the development of new drugs to combat infections. It is also used in the production of dyes and pigments. Additionally, it is utilized as a reagent in organic chemistry for the preparation of various organic compounds. However, it is important to handle this compound with caution, as it is considered toxic and may cause skin and eye irritation upon contact.

InChI:InChI=1/C7H7BrN2O/c8-6-4-2-1-3-5(6)7(11)10-9/h1-4H,9H2,(H,10,11)

Upstream product

• 6091-64-1 2-bromobenzoic acid ethyl ester 
• 88-65-3 2-bromobenzoic-acid 
• 610-94-6 2-bromobenzoic acid methyl ester 
• 7154-66-7 2-bromobenzoic acid chloride 
• 2142-69-0 2-bromophenyl methyl ketone 

Downstream Products

• 93418-02-1 furfural-(2-bromo-benzoylhydrazone) 
• 50625-50-8 2-bromo-benzoyl azide 
• 6630-33-7 ortho-bromobenzaldehyde 
• 292855-50-6 2-bromo-benzoic acid benzylidenehydrazide 
• 103040-18-2 2-bromo-benzoic acid isopropylidenehydrazide 
• 61055-40-1 5-(2-Bromophenyl)-4-amino-3-mercapto-4H-1,2,4-triazole 
• 130240-21-0 C₂₈H₁₈Br₂N₄O₂ 
• 39631-31-7 N¹-(o-bromobenzoyl)-3-thiosemicarbazide 

Relevant articles and documents

Antibacterial and Antiviral Activities of 1,3,4-Oxadiazole Thioether 4H-Chromen-4-one Derivatives

Various 1,3,4-oxadiazole thioether 4H-chromen-4-one derivatives were conceived. The title compounds demonstrated striking inhibitory effects againstXac,Psa, andXoo. EC50data exhibited that A8 (19.7 μg/mL) had better antibacterial activity againstXoothan myricetin, BT, and TC. Simultaneously, the mechanism of action of A8 had been verified by SEM. The results of anti-tobacco mosaic virus indicated that A9 had the bestin vivoantiviral effect compared with ningnanmycin. From the data of MST, it could be seen that A9 (0.003 ± 0.001 μmol/L) exhibited a strong binding capacity, which was far superior to ningnanmycin (2.726 ± 1.301 μmol/L). This study shows that the 1,3,4-oxadiazole thioether 4H-chromen-4-one derivatives may become agricultural drugs with great potential.

Synthesis and biological evaluation of honokiol derivatives bearing 3-((5-phenyl-1,3,4-oxadiazol-2-yl)methyl)oxazol-2(3h)-ones as potential viral entry inhibitors against sars-cov-2

The 2019 coronavirus disease (COVID-19) caused by SARS-CoV-2 virus infection has posed a serious danger to global health and the economy. However, SARS-CoV-2 medications that are specific and effective are still being developed. Honokiol is a bioactive component from Magnoliae officinalis Cortex with damp-drying effect. To develop new potent antiviral molecules, a series of novel honokiol analogues were synthesized by introducing various 3-((5-phenyl-1,3,4-oxadiazol-2-yl)methyl)oxazol-2(3H)-ones to its molecule. In a SARS-CoV-2 pseudovirus model, all honokiol derivatives were examined for their antiviral entry activities. As a result, 6a and 6p demonstrated antiviral entry effect with IC50 values of 29.23 and 9.82 μM, respectively. However, the parental honokiol had a very weak antiviral activity with an IC50 value more than 50 μM. A biolayer interfero-metry (BLI) binding assay and molecular docking study revealed that 6p binds to human ACE2 protein with higher binding affinity and lower binding energy than the parental honokiol. A competitive ELISA assay confirmed the inhibitory effect of 6p on SARS-CoV-2 spike RBD’s binding with ACE2. Importantly, 6a and 6p (TC50 > 100 μM) also had higher biological safety for host cells than honokiol (TC50 of 48.23 μM). This research may contribute to the discovery of potential viral entrance inhibitors for the SARS-CoV-2 virus, although 6p’s antiviral efficacy needs to be validated on SARS-CoV-2 viral strains in a biosafety level 3 facility.

Design, Synthesis, and Study of the Insecticidal Activity of Novel Steroidal 1,3,4-Oxadiazoles

A series of novel steroidal derivatives with a substituted 1,3,4-oxadiazole structure was designed and synthesized, and the target compounds were evaluated for their insecticidal activity against five aphid species. Most of the tested compounds exhibited potent insecticidal activity against Eriosoma lanigerum (Hausmann), Myzus persicae, and Aphis citricola. Compounds 20g and 24g displayed the highest activity against E. lanigerum, showing LC50 values of 27.6 and 30.4 μg/mL, respectively. Ultrastructural changes in the midgut cells of E. lanigerum were detected by transmission electron microscopy, indicating that these steroidal oxazole derivatives might exert their insecticidal activity by destroying the mitochondria and nuclear membranes in insect midgut cells. Furthermore, a field trial showed that compound 20g exhibited effects similar to those of the positive controls chlorpyrifos and thiamethoxam against E. lanigerum, reaching a control rate of 89.5% at a dose of 200 μg/mL after 21 days. We also investigated the hydrolysis and metabolism of the target compounds in E. lanigerum by assaying the activities of three insecticide-detoxifying enzymes. Compound 20g at 50 μg/mL exhibited inhibitory action on carboxylesterase similar to the known inhibitor triphenyl phosphate. The above results demonstrate the potential of these steroidal oxazole derivatives to be developed as novel pesticides.