294181-97-8 Usage
Ethyl ester derivative
The compound is an ethyl ester derivative of 2,2-difluoro-2-(quinolin-2-yl)acetic acid, meaning it has an ethoxy group attached to the parent compound.
α7 nicotinic acetylcholine receptor agonist
The compound is a selective agonist of the α7 nicotinic acetylcholine receptor, which means it binds to and activates this specific receptor in the nervous system.
Potential therapeutic applications
The compound has potential therapeutic applications, particularly in the treatment of neurodegenerative diseases such as Alzheimer's and schizophrenia.
Ongoing research and clinical trials
The unique structure and pharmacological properties of the compound make it a promising candidate for drug development, and it is currently being studied in ongoing research and clinical trials.
Check Digit Verification of cas no
The CAS Registry Mumber 294181-97-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,9,4,1,8 and 1 respectively; the second part has 2 digits, 9 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 294181-97:
(8*2)+(7*9)+(6*4)+(5*1)+(4*8)+(3*1)+(2*9)+(1*7)=168
168 % 10 = 8
So 294181-97-8 is a valid CAS Registry Number.
294181-97-8Relevant articles and documents
Manufacturing method of making heteroarylacetic compd. defluoromethyl
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Paragraph 0110-0112, (2018/10/03)
PROBLEM TO BE SOLVED: To provide a method for easily producing a difluoromethyl heteroaryl compound with high yield at low cost. SOLUTION: In the method for producing the difluoro methyl heteroaryl compound, a halogenated heteroaryl compound and a α-silyldifluoro acetate ester compound are reacted with each other in the presence of a metal halogenated compound. COPYRIGHT: (C)2012,JPOandINPIT
A new method for aromatic difluoromethylation: Copper-catalyzed cross-coupling and decarboxylation sequence from aryl iodides
Fujikawa, Kenichi,Fujioka, Yasutaka,Kobayashi, Akira,Amii, Hideki
supporting information; experimental part, p. 5560 - 5563 (2011/12/05)
A new methodology for aromatic difluoromethylation is described. Aryl iodides reacted with α-silyldifluoroacetates upon treatment with copper catalyst in DMSO or DME to give the corresponding aryldifluoroacetates in moderate to good yields. The subsequent hydrolysis of aryldifluoroacetates and KF-promoted decarboxylation afforded a variety of difluoromethyl aromatics.
