294202-82-7

Basic information

• Product Name: N⁶-(Dibutylaminomethylene)-9-(diphenylphosphorylmethyl)adenine
• Synonyms: N⁶-(Dibutylaminomethylene)-9-(diphenylphosphorylmethyl)adenine
• CAS NO: 294202-82-7
• Molecular Weight: 488.572
• Mol File: 294202-82-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N⁶-(Dibutylaminomethylene)-9-(diphenylphosphorylmethyl)adenine(CAS DataBase Reference)
• NIST Chemistry Reference: N⁶-(Dibutylaminomethylene)-9-(diphenylphosphorylmethyl)adenine(294202-82-7)
• EPA Substance Registry System: N⁶-(Dibutylaminomethylene)-9-(diphenylphosphorylmethyl)adenine(294202-82-7)

Safety Data

• Hazardous Substances Data: 294202-82-7(Hazardous Substances Data)

Upstream product

• 19449-30-0 N,N-dibutylformamide dimethyl acetal 
• 33730-73-3 (4-Nitrophenylsulfonyloxymethyl)diphenylphosphine oxide 
• 66224-66-6 adenine 

Relevant articles and documents

Preparation of N-(alk-1-enyl) nucleobase compounds by Horner and Horner-Wadsworth-Emmons reactions

A series of new N9-(alk-1-enyl)adenines and N1-(alk-1-enyl)thymines has been prepared by Homer reactions of the new phosphine oxides N9 -(diphenylphosphorylmethyl)adenine and N1-(diphenylphosphorylmethyl)thymine derivatives 13a-c, or Horner-Wadsworth-Emmons reactions of the corresponding new phosphonates 14a-b, with benzaldehyde and various ketones. Yields were highest for the Homer reactions (10-79%), and were limited by steric hindrance, enolization of the ketones, and decomposition of some of the N1-(alk-1-enyl)thymines in the presence of excess base (NaH). Butanal gave mixtures of products under Homer conditions, probably because aldol reactions intervened.