29427-70-1

Basic information

• Product Name: Methyl 3-oxo-2,3-dihydro-1H-indene-1-carboxylate
• Synonyms: Methyl 3-oxo-2,3-dihydro-1H-indene-1-carboxylate
• CAS NO: 29427-70-1
• Molecular Formula: C₁₁H₁₀O₃
• Molecular Weight: 190.1953
• Mol File: 29427-70-1.mol
• Article Data: 14

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: Methyl 3-oxo-2,3-dihydro-1H-indene-1-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl 3-oxo-2,3-dihydro-1H-indene-1-carboxylate(29427-70-1)
• EPA Substance Registry System: Methyl 3-oxo-2,3-dihydro-1H-indene-1-carboxylate(29427-70-1)

Safety Data

• Hazardous Substances Data: 29427-70-1(Hazardous Substances Data)

Usage

Description

Methyl 3-oxo-2,3-dihydro-1H-indene-1-carboxylate, also known as Methyl 3-Oxoindane-1-carboxylate, is an organic compound that serves as an essential intermediate in the synthesis of various biologically active molecules. It is characterized by its unique chemical structure, which includes a methyl ester group and a 3-oxo-2,3-dihydro-1H-indene-1-carboxylate moiety.

Uses

Used in Pharmaceutical Industry:
Methyl 3-oxo-2,3-dihydro-1H-indene-1-carboxylate is used as a reactant for the synthesis of purinyland pyrimidinylcarbanucleosides, which possess antiviral activities. These synthesized compounds have potential applications in the development of new antiviral drugs, targeting a wide range of viral infections.

Upstream product

• 67-56-1 methanol 
• 29427-69-8 3-oxoindan-1-carboxylic acid 
• 201230-82-2 carbon monoxide 
• 4840-91-9 o-iodostyrene 
• 799804-36-7 methyl 2-(2-{2-[(methylsulfonyloxy)oxy]acetyl}phenyl)acetate 
• 1131-15-3 2-phenylsuccinic anhydride 
• 66370-75-0 methyl (2-iodophenyl)acetate 
• 16535-88-9 (2-acetyk-phenyl)-acetic acid methyl ester 
• 637348-19-7 (2-ethynylphenyl)acetic acid methyl ester 
• 799804-49-2 (2-trimethylsilanylethynyl-phenyl)-acetic acid methyl ester 
• 27973-23-5 3-methoxy-1H-indene 
• 83-33-0 inden-1-one 
• 635-51-8 2-phenylsuccinic acid 
• 75-85-4 tert-Amyl alcohol 

Downstream Products

• 185122-64-9 Methyl 3-hydroxyimino-1-indanecarboxylate 
• 357426-12-1 methyl 3-(aminomethyl)indan-1-carboxylate 
• 357426-13-2 1,5-methano-2-oxo-2,3,4,5-tetrahydro-1H-3-benzazepine 
• 357425-93-5 1,5-methano-2,3,4,5-tetrahydro-1H-3-benzazepine p-toluenesulfonic acid salt 
• 111634-91-4 Methyl (+/-)-cis-3-amino-1-indanecarboxylate 
• 185122-65-0 Methyl (+/-)-trans-3-amino-1-indanecarboxylate 
• 91948-71-9 C₂₁H₂₁NO₄S 
• 132205-76-6 1-cyano-5-chloro-2,3-dihydro-1H-indene 
• 1415502-42-9 methyl (3S)-3-{[(1S)-1-(4-methoxyphenyl)ethyl]amino}indane-1-carboxylate 
• 60031-28-9 2-benzal-3-oxoindancarboxylic acid 
• 60031-26-7 2-benzylidene-3-methoxycarbonyl-1-indanone 
• 93321-72-3 2-benzyl-3-oxo-1-indancarboxylic acid 

Relevant articles and documents

Compound as potassium channel modulator

The invention relates to a compound as a potassium channel modulator, which is a compound of a formula (I) or a pharmaceutically acceptable salt thereof. The compound or the pharmaceutically acceptable salt thereof is effective for curing and preventing diseases and symptoms influenced by the activity of potassium ion channels.

Photochemical preparation of highly functionalized 1-indanones

A series of o-alkylphenyl alkyl ketones 1 were synthesized by different methods. The presence of a leaving group X adjacent to the carbonyl group is the special peculiarity of these ketones. Upon irradiation the keto carbonyl group of these compounds undergoes an n-π* excitation followed by a 1,5-hydrogen migration from the o-alkyl substituent to the carbonyl oxygen atom. The thus formed 1,4-diradicals are subject to a very rapid elimination of acid HX, giving 1,5-diradicals. We called this process spin center shift. After intersystem crossing these diradicals cyclize to 1-indanones 20 in good yields. Depending on the solvent and on substituents, o-alkoxyalkyl ketones 22 or benzo-[c]furanes 21 are obtained as byproducts. The mechanism of the cyclization was elucidated by quantum chemical calculations and kinetic measurements.

A general route to the synthesis of 1,5-methano- and 1,5-ethano-2, 3,4,5-tetrahydro-1h-3-benzazepines

A general approach to preparing 1,5-methano-(1) and l,5-ethano-2,3,4,5- tetrahydro-lff-3-benzazepine (2) is discussed. This strategy involves converting an indanone or tetralone (4) to a cyanohydrin (3) which is subjected to hydrogenolysis followed by lac