2944-11-8

Basic information

• Product Name: 4-(octadecyloxy)-4-oxobutanoic acid
• Synonyms: 4-(Octadecyloxy)-4-oxobutanoic acid; butanedioic acid, monooctadecyl ester
• CAS NO: 2944-11-8
• Molecular Formula: C₂₂H₄₂O₄
• Molecular Weight: 370.5665
• Mol File: 2944-11-8.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 483.8°C at 760 mmHg
• Flash Point: 152.8°C
• Density: 0.95g/cm³
• Vapor Pressure: 1.1E-10mmHg at 25°C
• Refractive Index: 1.462
• CAS DataBase Reference: 4-(octadecyloxy)-4-oxobutanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(octadecyloxy)-4-oxobutanoic acid(2944-11-8)
• EPA Substance Registry System: 4-(octadecyloxy)-4-oxobutanoic acid(2944-11-8)

Safety Data

• Hazardous Substances Data: 2944-11-8(Hazardous Substances Data)

Upstream product

• 108-30-5 succinic acid anhydride 
• 112-92-5 1-octadecanol 
• 92803-46-8 Succinic acid octadecyl ester 2-trimethylsilanyl-ethyl ester 

Relevant articles and documents

Optimization of gefitinib analogues with potent anticancer activity

The interactions of gefitinib (Iressa) in EGFR are hydrogen bonding and van der Waals forces through quinazoline and aniline rings. However the morpholino group of gefitinib is poorly ordered due to its weak electron density. A series of novel piperazino analogues of gefitinib where morpholino group substituted with various piperazino groups were designed and synthesized. Most of them indicated significant anti-cancer activities against human cancer cell lines. In particular, compounds 52-54 showed excellent potency against cancer cells. Convergent synthetic approach has been developed for the synthesis of gefitinib intermediate which can lead to gefitinib as well as numerous analogues.

Preparation and characteristics of silica-based packings for high-performance liquid chromatography modified with amino and carboxyl groups

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