2944-96-9

Basic information

• Product Name: Benzenemethanamine,3-(trifluoromethyl)-, hydrochloride (1:1)
• Synonyms: Benzenemethanamine,3-(trifluoromethyl)-, hydrochloride (9CI); Benzylamine, m-(trifluoromethyl)-,hydrochloride (7CI,8CI)
• CAS NO: 2944-96-9
• Molecular Formula: C₈H₈F₃N*ClH
• Molecular Weight: 175.151
• Mol File: 2944-96-9.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 180.6°Cat760mmHg
• Flash Point: 71.1°C
• Density: 1.225g/cm³
• CAS DataBase Reference: Benzenemethanamine,3-(trifluoromethyl)-, hydrochloride (1:1)(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenemethanamine,3-(trifluoromethyl)-, hydrochloride (1:1)(2944-96-9)
• EPA Substance Registry System: Benzenemethanamine,3-(trifluoromethyl)-, hydrochloride (1:1)(2944-96-9)

Safety Data

• Hazardous Substances Data: 2944-96-9(Hazardous Substances Data)

Upstream product

• 368-77-4 3-trifluoromethylbenzonitrile 
• 620533-90-6 1‐(azidomethyl)‐3‐(trifluoromethyl)benzene 
• 1801-10-1 3-trifluoromethylbenzamide 
• 2740-83-2 3-(TRIFLUOROMETHYL)BENZYLAMINE 

Relevant articles and documents

Benzimidazole fragment containing Mn-complex catalyzed hydrosilylation of ketones and nitriles

The synthesis of a new bidentate (NN)–Mn(I) complex is reported and its catalytic activity towards the reduction of ketones and nitriles is studied. On comparing the reactivity of various other Mn(I) complexes supported by benzimidazole ligand, it was observed that the Mn(I) complexes bearing 6-methylpyridine and benzimidazole fragments exhibited the highest catalytic activity towards monohydrosilylation of ketones and dihydrosilylation of nitriles. Using this protocol, a wide range of ketones were selectively reduced to the corresponding silyl ethers. In case of unsaturated ketones, the chemoselective reduction of carbonyl group over olefinic bonds was observed. Additionally, selective dihydrosilylation of several nitriles were also achieved using this complex. Mechanistic investigations with radical scavengers suggested the involvement of radical species during the catalytic reaction. Stoichiometric reaction of the Mn(I) complex with phenylsilane revealed the formation of a new Mn(I) complex.

Synthesis of Molybdenum Pincer Complexes and Their Application in the Catalytic Hydrogenation of Nitriles

A series of molybdenum(0), (I) and (II) complexes ligated by different PNP and NNN pincer ligands were synthesized and structurally characterized. Along with previously described Mo?PNP complexes Mo-1 and Mo-2, all prepared compounds were tested in the catalytic hydrogenation of aromatic nitriles to primary amines. Among the applied catalysts, Mo-1 is particularly well suited for the hydrogenation of electron-rich benzonitriles. Additionally, two aliphatic nitriles were transformed into the desired products in 80 and 86 percent, respectively. Moreover, catalytic intermediate Mo-1a was isolated and its role in the catalytic cycle was subsequently demonstrated.

Exhaustive Chemoselective Reduction of Nitriles by Catalytic Hydrosilylation Involving Cooperative Si-H Bond Activation

A chemoselective method for the catalytic hydrosilylation of nitriles to either the imine or amine oxidation level is reported. The chemoselectivity is controlled by the hydrosilane used. The usefulness of the nitrile-to-amine reduction is demonstrated for a diverse set of aromatic and aliphatic nitriles, and the amines are easily isolated after hydrolysis as their hydrochloride salts. This exhaustive nitrile reduction proceeds at room temperature.