29460-92-2 Usage
General Description
2-Isobutylpyrazine is an aromatic organic compound that belongs to the group of alkylpyrazines, which are heterocycles made up of a pyrazine ring with an alkyl group attached to it. This chemical is found in a variety of foods such as peas, wine, and coffee, and is responsible for contributing to their unique flavors. Because of its strong, peculiar smell that's often described as "earthy" or "nutty", 2-Isobutylpyrazine is commonly used in the food and beverage industry as a flavor additive. Notably, its presence has also been detected in certain insects like ladybugs. Despite its widespread use, it's generally present in very low quantities due to its potent aroma and taste.
Check Digit Verification of cas no
The CAS Registry Mumber 29460-92-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,9,4,6 and 0 respectively; the second part has 2 digits, 9 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 29460-92:
(7*2)+(6*9)+(5*4)+(4*6)+(3*0)+(2*9)+(1*2)=132
132 % 10 = 2
So 29460-92-2 is a valid CAS Registry Number.
InChI:InChI=1/C8H12N2/c1-7(2)5-8-6-9-3-4-10-8/h3-4,6-7H,5H2,1-2H3
29460-92-2Relevant articles and documents
Manganese-Catalyzed Kumada Cross-Coupling Reactions of Aliphatic Grignard Reagents with N-Heterocyclic Chlorides
Petel, Brittney E.,Purak, Merjema,Matson, Ellen M.
supporting information, p. 1700 - 1706 (2018/07/13)
Herein we report the use of manganese(II) chloride for the catalytic generation of C(sp 2)-C(sp 3) bonds via Kumada cross-coupling. Rapid and selective formation of 2-alkylated N-heterocyclic complexes were observed in high yields with use of 3 mol% MnCl 2 THF 1.6 and under ambient reaction conditions (21 °C, 15 min to 20 h). Manganese-catalyzed cross-coupling is tolerant toward both electron-donating and electron-withdrawing functional groups in the 5-position of the pyridine ring, with the latter resulting in an increased reaction rate and a decrease in the amount of nucleophile required. The use of this biologically and environmentally benign metal salt as a catalyst for C-C bond formation highlights its potential as a catalyst for the late-stage functionalization of pharmaceutically active N-heterocyclic molecules (e.g., pyridine, pyrazine).
